Actifed and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride), especially for people who are female, 40-49 old, also take Simponi, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Actifed. It is created by eHealthMe based on reports of 991 people who have side effects when taking Actifed from the FDA, and is updated regularly.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,229 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 13, 2026

991 people reported to have side effects when taking Actifed.
Among them, 49 people (4.94%) have Knee joint replacement.

Could Actifed cause Knee joint replacement?

Among these 49 people:

What is the gender of people who have Knee joint replacement when taking Actifed? *

female: 100 %
male: 0.0 %

What is the age of people who have Knee joint replacement when taking Actifed? *

What are other drugs people take besides Actifed? *

What are other side effects people have besides Knee joint replacement? *

Glossodynia (a burning or painful sensation in the tongue): 49 people, 100.00%
Rheumatoid Factor Positive: 47 people, 95.92%
Fatigue (feeling of tiredness): 45 people, 91.84%
Hypersensitivity: 45 people, 91.84%
Hair Loss: 45 people, 91.84%
Pain: 45 people, 91.84%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 45 people, 91.84%
Hepatic Enzyme Increased: 45 people, 91.84%
Discomfort: 45 people, 91.84%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 45 people, 91.84%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 48 people, 97.96%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 38 people, 77.55%
Psoriasis (immune-mediated disease that affects the skin): 38 people, 77.55%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 37 people, 75.51%
Ankylosing Spondylitis (type of arthritis affecting the spine): 33 people, 67.35%
Stress And Anxiety: 10 people, 20.41%
Pain: 8 people, 16.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 12.24%
Fever: 5 people, 10.20%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

Do you take Actifed and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actifed:

Actifed (1,091 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,755 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Actifed

Expand to all the drugs that have ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride:

Knee joint replacement and drugs with ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride (13 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actifed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,229 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pseudoephedrine hydrochloride; triprolidine hydrochloride (the active ingredients of Actifed) and Actifed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.