Actiq and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Actiq (fentanyl citrate), especially for people who are male, 50-59 old, have been taking the drug for 6 - 12 months also take Duragesic-100, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Heart attack when taking Actiq. It is created by eHealthMe based on reports of 27,560 people who have side effects when taking Actiq from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Heart attack?

Heart attack is found to be associated with 2,514 drugs and 3,286 conditions by eHealthMe. Check the latest studies of Heart attack.

On Jan, 20, 2026

27,560 people reported to have side effects when taking Actiq.
Among them, 32 people (0.12%) have Heart attack.

Among these 32 people:

How long have people been on Actiq when they have Heart attack? *

What is the gender of people who have Heart attack when taking Actiq? *

female: 25 %
male: 75 %

What is the age of people who have Heart attack when taking Actiq? *

What are other drugs people take besides Actiq? *

What are other side effects people have besides Heart attack? *

Depression: 17 people, 53.12%
Constipation: 15 people, 46.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 43.75%
Stress And Anxiety: 14 people, 43.75%
Injury: 14 people, 43.75%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 14 people, 43.75%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 40.62%
Dyspnea (difficult or laboured breathing): 13 people, 40.62%
Drug Dependence: 13 people, 40.62%
Weakness: 13 people, 40.62%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 34.38%
High Blood Pressure: 5 people, 15.62%
Nausea (feeling of having an urge to vomit): 4 people, 12.50%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 3 people, 9.38%
Back Pain: 3 people, 9.38%
Breakthrough Pain: 3 people, 9.38%
Cancer Pain: 3 people, 9.38%
Constipation: 3 people, 9.38%
Neck Pain: 3 people, 9.38%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Actiq and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actiq:

Actiq (27,583 reports)

Heart attack treatments and more:

Heart attack (266,142 reports)

Browse all side effects of Actiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Heart attack (2,514 drugs)

Browse all the conditions that are associated with Heart attack:

Heart attack (3,286 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Actiq) and Actiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.