Actiq and Malignant pleural effusion - a phase IV clinical study of FDA data

Summary:

Malignant pleural effusion is reported as a side effect among people who take Actiq (fentanyl citrate), especially for people who are male, 50-59 old, also take Zometa, and have Metastases to bone.

The phase IV clinical study analyzes which people have Malignant pleural effusion when taking Actiq. It is created by eHealthMe based on reports of 27,560 people who have side effects when taking Actiq from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Malignant pleural effusion?

Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung) is found to be associated with 354 drugs and 448 conditions by eHealthMe. Check the latest studies of Malignant pleural effusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

27,560 people reported to have side effects when taking Actiq.
Among them, 22 people (0.08%) have Malignant pleural effusion.

Could Actiq cause Malignant pleural effusion?

Among these 22 people:

What is the gender of people who have Malignant pleural effusion when taking Actiq? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Malignant pleural effusion when taking Actiq? *

What are other drugs people take besides Actiq? *

What are other side effects people have besides Malignant pleural effusion? *

Pain In Jaw: 20 people, 90.91%
Toothaches (tooth pain): 20 people, 90.91%
Bone Disorder: 20 people, 90.91%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 20 people, 90.91%
Dyspnea (difficult or laboured breathing): 18 people, 81.82%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 18 people, 81.82%
Pain In Extremity: 17 people, 77.27%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 17 people, 77.27%
Pleural Effusion (water on the lungs): 17 people, 77.27%
Pneumonia: 17 people, 77.27%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 17 people, 77.27%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 13.64%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 3 people, 13.64%
High Blood Pressure: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Actiq and have Malignant pleural effusion?

- Check whether Malignant pleural effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actiq:

Actiq (27,583 reports)

Browse all side effects of Actiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malignant pleural effusion:

Malignant pleural effusion (354 drugs)

Browse all the conditions that are associated with Malignant pleural effusion:

Malignant pleural effusion (448 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Actiq) and Actiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.