1. Home
  2. Analysis
  3. Actiq
  4. Multiple-sclerosis

Actiq and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Actiq (fentanyl citrate), especially for people who are male, 50-59 old, also take Paracetamol, and have Pain in extremity.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Actiq. It is created by eHealthMe based on reports of 27,560 people who have side effects when taking Actiq from the FDA, and is updated regularly.

What is Actiq?

Actiq has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 27,583 Actiq users. Check the latest studies of Actiq.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,131 drugs and 1,347 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Dec, 30, 2025

27,560 people reported to have side effects when taking Actiq.
Among them, 16 people (0.06%) have Multiple sclerosis.

Could Actiq cause Multiple sclerosis?

Among these 16 people:

What is the gender of people who have Multiple sclerosis when taking Actiq? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Multiple sclerosis when taking Actiq? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 7.69 %
  • 50-59: 92.31 %
  • 60+: 0.0 %

What are other drugs people take besides Actiq? *

  1. Morphine: 7 people, 43.75%
  2. Paracetamol: 7 people, 43.75%
  3. Fentanyl Transdermal System: 4 people, 25.00%
  4. Oxycontin: 4 people, 25.00%
  5. Avonex: 4 people, 25.00%
  6. Soma: 3 people, 18.75%
  7. Celebrex: 3 people, 18.75%
  8. Lortab: 2 people, 12.50%
  9. Reglan: 2 people, 12.50%
  10. Neurontin: 2 people, 12.50%

What are other side effects people have besides Multiple sclerosis? *

  1. Constipation: 8 people, 50.00%
  2. Urinary Retention (the inability to completely or partially empty the bladder): 7 people, 43.75%
  3. Disease Progression: 7 people, 43.75%
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 7 people, 43.75%
  5. Paraplegia (paralysis of the legs and lower body): 7 people, 43.75%
  6. Gastric Ulcer (stomach ulcer): 7 people, 43.75%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 25.00%
  8. Blindness Unilateral: 3 people, 18.75%
  9. High Blood Pressure: 3 people, 18.75%
  10. Gingival Abscess (pus in gums): 3 people, 18.75%

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 6.25%
  2. Pain In Extremity: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Actiq and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition (FREE)
- Predict drug outcomes for up to one year with AI (FREE)
- Get an AI agent to monitor your drugs continuously (FREE)

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actiq:

Multiple sclerosis treatments and more:

How severe was Multiple sclerosis and when was it recovered:

Expand to all the drugs that have ingredients of fentanyl citrate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Browse all the conditions that are associated with Multiple sclerosis:

Drugs similar to Actiq and Multiple sclerosis :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Actiq) and Actiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2025 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.