Activase and Activated partial thromboplastin time prolonged - a phase IV clinical study of FDA data

Summary:

Activated partial thromboplastin time prolonged is reported as a side effect among people who take Activase (alteplase), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Heparin, and have Pulmonary embolism.

The phase IV clinical study analyzes which people have Activated partial thromboplastin time prolonged when taking Activase. It is created by eHealthMe based on reports of 7,505 people who have side effects when taking Activase from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Activated partial thromboplastin time prolonged?

Activated partial thromboplastin time prolonged is found to be associated with 761 drugs and 1,208 conditions by eHealthMe. Check the latest studies of Activated partial thromboplastin time prolonged.

On Jul, 02, 2026

7,505 people reported to have side effects when taking Activase.
Among them, 44 people (0.59%) have Activated partial thromboplastin time prolonged.

Could Activase cause Activated partial thromboplastin time prolonged?

Among these 44 people:

How long have people been on Activase when they have Activated partial thromboplastin time prolonged? *

What is the gender of people who have Activated partial thromboplastin time prolonged when taking Activase? *

female: 45.24 %
male: 54.76 %

What is the age of people who have Activated partial thromboplastin time prolonged when taking Activase? *

What are other drugs people take besides Activase? *

What are other side effects people have besides Activated partial thromboplastin time prolonged? *

Hypotension (abnormally low blood pressure): 11 people, 25.00%
Haematocrit Decreased: 8 people, 18.18%
Haemoglobin Decreased: 7 people, 15.91%
Chest Pain: 7 people, 15.91%
Haematemesis (vomiting of blood): 7 people, 15.91%
Depressed Level Of Consciousness: 5 people, 11.36%
High Blood Pressure: 5 people, 11.36%
International Normalised Ratio Increased: 4 people, 9.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.09%
Nausea (feeling of having an urge to vomit): 4 people, 9.09%

What are the existing conditions these people have? *

Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 9.09%
Vena Cava Thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart): 1 person, 2.27%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.27%
Heparin-Induced Thrombocytopenia: 1 person, 2.27%
Heart Attack: 1 person, 2.27%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 2.27%
Bacteraemia (presence of bacteria in the blood): 1 person, 2.27%
Acute Myocardial Infarction (acute heart attack): 1 person, 2.27%
Acute Leukaemia (blood cancer): 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Activase and have Activated partial thromboplastin time prolonged?

- Check whether Activated partial thromboplastin time prolonged is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activase:

Activase (7,526 reports)

Activated partial thromboplastin time prolonged treatments and more:

Activated partial thromboplastin time prolonged (8,799 reports)

How severe was Activated partial thromboplastin time prolonged and when was it recovered:

Activated partial thromboplastin time prolonged in Activase

Expand to all the drugs that have ingredients of alteplase:

Activated partial thromboplastin time prolonged and drugs with ingredients of alteplase (57 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Activated partial thromboplastin time prolonged:

Activated partial thromboplastin time prolonged (761 drugs)

Browse all the conditions that are associated with Activated partial thromboplastin time prolonged:

Activated partial thromboplastin time prolonged (1,208 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alteplase (the active ingredients of Activase) and Activase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.