Activase and Sciatic nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Sciatic nerve dysfunction is reported as a side effect among people who take Activase (alteplase), especially for people who are male, 50-59 old, also take Percocet, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Sciatic nerve dysfunction when taking Activase. It is created by eHealthMe based on reports of 7,505 people who have side effects when taking Activase from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Sciatic nerve dysfunction?

Sciatic nerve dysfunction (a condition in which the sciatic nerve conducts impulses abnormally) is found to be associated with 1,942 drugs and 1,447 conditions by eHealthMe. Check the latest studies of Sciatic nerve dysfunction.

On Dec, 01, 2025

7,505 people reported to have side effects when taking Activase.
Among them, 11 people (0.15%) have Sciatic nerve dysfunction.

Could Activase cause Sciatic nerve dysfunction?

Among these 11 people:

What is the gender of people who have Sciatic nerve dysfunction when taking Activase? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Sciatic nerve dysfunction when taking Activase? *

What are other drugs people take besides Activase? *

What are other side effects people have besides Sciatic nerve dysfunction? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 100.00%
Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 100.00%
Pain: 11 people, 100.00%
Arthropathy: 11 people, 100.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 11 people, 100.00%
Pleural Fibrosis (formation of fibrous tissue in lung): 11 people, 100.00%
Depression: 11 people, 100.00%
Haematochezia (passage of stools containing blood): 11 people, 100.00%
Stress And Anxiety: 11 people, 100.00%
Exostosis (formation of new bone on the surface of a bone): 11 people, 100.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 90.91%
Osteoporosis (bones weak and more likely to break): 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 9.09%
Birth Control: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Activase and have Sciatic nerve dysfunction?

- Check whether Sciatic nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activase:

Activase (7,526 reports)

Browse all side effects of Activase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,942 drugs)

Browse all the conditions that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,447 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alteplase (the active ingredients of Activase) and Activase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.