Activase and Tendon rupture - a phase IV clinical study of FDA data

Summary:

Tendon rupture is reported as a side effect among people who take Activase (alteplase), especially for people who are female, 50-59 old, also take Flonase, and have Bone density abnormal.

The phase IV clinical study analyzes which people have Tendon rupture when taking Activase. It is created by eHealthMe based on reports of 7,505 people who have side effects when taking Activase from the FDA, and is updated regularly.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

What is Tendon rupture?

Tendon rupture (tear of tendon) is found to be associated with 803 drugs and 1,060 conditions by eHealthMe. Check the latest studies of Tendon rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

7,505 people reported to have side effects when taking Activase.
Among them, 14 people (0.19%) have Tendon rupture.

Among these 14 people:

What is the gender of people who have Tendon rupture when taking Activase? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Tendon rupture when taking Activase? *

What are other drugs people take besides Activase? *

What are other side effects people have besides Tendon rupture? *

Cough: 14 people, 100.00%
Upper-Airway Cough Syndrome: 14 people, 100.00%
Neuropathy Peripheral (surface nerve damage): 14 people, 100.00%
Depression: 14 people, 100.00%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 14 people, 100.00%
Pain: 14 people, 100.00%
Insomnia (sleeplessness): 14 people, 100.00%
Musculoskeletal Chest Pain (pain in chest muscle or nerve or bones): 14 people, 100.00%
Nausea (feeling of having an urge to vomit): 14 people, 100.00%
Cyst (a closed sac): 12 people, 85.71%

What are the existing conditions these people have? *

Bone Density Abnormal: 10 people, 71.43%
Osteoporosis (bones weak and more likely to break): 5 people, 35.71%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.14%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Activase and have Tendon rupture?

- Check whether Tendon rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activase:

Activase (7,526 reports)

Tendon rupture treatments and more:

Tendon rupture (15,907 reports)

Browse all side effects of Activase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tendon rupture:

Tendon rupture (803 drugs)

Browse all the conditions that are associated with Tendon rupture:

Tendon rupture (1,060 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alteplase (the active ingredients of Activase) and Activase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.