Activella and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Activella (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Wellbutrin, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Constipation when taking Activella. It is created by eHealthMe based on reports of 1,837 people who have side effects when taking Activella from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,597 conditions by eHealthMe. Check the latest studies of Constipation.

On Mar, 03, 2026

1,837 people reported to have side effects when taking Activella.
Among them, 28 people (1.52%) have Constipation.

Among these 28 people:

How long have people been on Activella when they have Constipation? *

What is the gender of people who have Constipation when taking Activella? *

female: 100 %
male: 0.0 %

What is the age of people who have Constipation when taking Activella? *

What are other drugs people take besides Activella? *

What are other side effects people have besides Constipation? *

Abdominal Pain Upper: 10 people, 35.71%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 35.71%
Back Pain: 10 people, 35.71%
Nausea (feeling of having an urge to vomit): 10 people, 35.71%
Diarrhea: 9 people, 32.14%
Weakness: 8 people, 28.57%
Fatigue (feeling of tiredness): 8 people, 28.57%
High Blood Pressure: 8 people, 28.57%
Dyspnea (difficult or laboured breathing): 8 people, 28.57%
Swallowing Difficulty: 8 people, 28.57%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 5 people, 17.86%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 14.29%
Pain: 3 people, 10.71%
Indigestion: 3 people, 10.71%
Osteoporosis (bones weak and more likely to break): 3 people, 10.71%
Irritable Bowel Syndrome: 3 people, 10.71%
Rashes (redness): 2 people, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 7.14%
Folliculitis (infection of hair root): 2 people, 7.14%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Activella and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activella:

Activella (1,971 reports)

Constipation treatments and more:

Constipation (337,872 reports)

How severe was Constipation and when was it recovered:

Constipation in Activella

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Constipation and drugs with ingredients of estradiol; norethindrone acetate (54 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,597 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Activella) and Activella (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.