Activella and Fall - a phase IV clinical study of FDA data

Summary:

Fall is reported as a side effect among people who take Activella (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Avelox, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Fall when taking Activella. It is created by eHealthMe based on reports of 1,837 people who have side effects when taking Activella from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Fall?

Fall is found to be associated with 3,280 drugs and 3,756 conditions by eHealthMe. Check the latest studies of Fall.

On Jun, 15, 2026

1,837 people reported to have side effects when taking Activella.
Among them, 52 people (2.83%) have Fall.

Among these 52 people:

How long have people been on Activella when they have Fall? *

What is the gender of people who have Fall when taking Activella? *

female: 98.08 %
male: 1.92 %

What is the age of people who have Fall when taking Activella? *

What are other drugs people take besides Activella? *

What are other side effects people have besides Fall? *

Pain: 31 people, 59.62%
Bone Disorder: 29 people, 55.77%
Stress And Anxiety: 29 people, 55.77%
Loose Tooth: 28 people, 53.85%
Tooth Disorder (tooth disease): 28 people, 53.85%
Osteoporosis (bones weak and more likely to break): 28 people, 53.85%
Osteonecrosis Of Jaw (death of bone of jaw): 28 people, 53.85%
Sensitivity Of Teeth: 27 people, 51.92%
Sinusitis (inflammation of sinus): 24 people, 46.15%
Femur Fracture: 23 people, 44.23%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 12 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 9.62%
Gait Disturbance: 5 people, 9.62%
Pain: 4 people, 7.69%
Ill-Defined Disorder: 3 people, 5.77%
Osteoporosis (bones weak and more likely to break): 3 people, 5.77%
Back Pain: 3 people, 5.77%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 3.85%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 1.92%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 1 person, 1.92%

* Approximation only. Some reports may have incomplete information.

Do you take Activella and have Fall?

- Check whether Fall is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activella:

Activella (1,971 reports)

Fall treatments and more:

Fall (403,513 reports)

How severe was Fall and when was it recovered:

Fall in Activella

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Fall and drugs with ingredients of estradiol; norethindrone acetate (119 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fall:

Fall (3,280 drugs)

Browse all the conditions that are associated with Fall:

Fall (3,756 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Activella) and Activella (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.