Activella and Hyperhidrosis - a phase IV clinical study of FDA data

Summary:

Hyperhidrosis is reported as a side effect among people who take Activella (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Hydrochlorothiazide, and have Depression.

The phase IV clinical study analyzes which people have Hyperhidrosis when taking Activella. It is created by eHealthMe based on reports of 1,837 people who have side effects when taking Activella from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Hyperhidrosis?

Hyperhidrosis (abnormally increased sweating) is found to be associated with 2,539 drugs and 3,546 conditions by eHealthMe. Check the latest studies of Hyperhidrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,837 people reported to have side effects when taking Activella.
Among them, 12 people (0.65%) have Hyperhidrosis.

Among these 12 people:

How long have people been on Activella when they have Hyperhidrosis? *

What is the gender of people who have Hyperhidrosis when taking Activella? *

female: 100 %
male: 0.0 %

What is the age of people who have Hyperhidrosis when taking Activella? *

What are other drugs people take besides Activella? *

What are other side effects people have besides Hyperhidrosis? *

Dizziness: 5 people, 41.67%
Abdominal Pain Upper: 4 people, 33.33%
Hot Flush (sudden feelings of heat): 4 people, 33.33%
Insomnia (sleeplessness): 4 people, 33.33%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 33.33%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 33.33%
Panic Disorder: 3 people, 25.00%
Depression: 3 people, 25.00%
Crying: 3 people, 25.00%
Weight Increased: 3 people, 25.00%

What are the existing conditions these people have? *

Depression: 3 people, 25.00%
Pain: 2 people, 16.67%
Bipolar Disorder (mood disorder): 2 people, 16.67%
Nausea And Vomiting: 1 person, 8.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%
Menopausal Symptoms: 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Activella and have Hyperhidrosis?

- Check whether Hyperhidrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activella:

Activella (1,971 reports)

Hyperhidrosis treatments and more:

Hyperhidrosis (147,206 reports)

How severe was Hyperhidrosis and when was it recovered:

Hyperhidrosis in Activella

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Hyperhidrosis and drugs with ingredients of estradiol; norethindrone acetate (74 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperhidrosis:

Hyperhidrosis (2,539 drugs)

Browse all the conditions that are associated with Hyperhidrosis:

Hyperhidrosis (3,546 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Activella) and Activella (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.