Activella and Itching - a phase IV clinical study of FDA data

Summary:

Itching is reported as a side effect among people who take Activella (estradiol; norethindrone acetate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin E, and have Asthma.

The phase IV clinical study analyzes which people have Itching when taking Activella. It is created by eHealthMe based on reports of 1,837 people who have side effects when taking Activella from the FDA, and is updated regularly.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

What is Itching?

Itching is found to be associated with 3,223 drugs and 4,504 conditions by eHealthMe. Check the latest studies of Itching.

On Nov, 21, 2025

1,837 people reported to have side effects when taking Activella.
Among them, 18 people (0.98%) have Itching.

Among these 18 people:

How long have people been on Activella when they have Itching? *

What is the gender of people who have Itching when taking Activella? *

female: 100 %
male: 0.0 %

What is the age of people who have Itching when taking Activella? *

What are other drugs people take besides Activella? *

What are other side effects people have besides Itching? *

Nausea (feeling of having an urge to vomit): 10 people, 55.56%
Rashes (redness): 9 people, 50.00%
Diarrhea: 9 people, 50.00%
Fever: 6 people, 33.33%
Weakness: 4 people, 22.22%
Burning Sensation: 4 people, 22.22%
Pain: 4 people, 22.22%
Loss Of Consciousness: 4 people, 22.22%
Depression: 4 people, 22.22%
Dizziness: 4 people, 22.22%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 22.22%
Asthma: 4 people, 22.22%
Sinusitis (inflammation of sinus): 3 people, 16.67%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.56%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 1 person, 5.56%
Multiple Allergies (allergy to multiple agents): 1 person, 5.56%
Lower Respiratory Tract Infection: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
High Blood Cholesterol: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Activella and have Itching?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Activella:

Activella (1,971 reports)

Itching treatments and more:

Itching (398,805 reports)

How severe was Itching and when was it recovered:

Itching in Activella

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Itching and drugs with ingredients of estradiol; norethindrone acetate (47 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Activella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Itching:

Itching (3,223 drugs)

Browse all the conditions that are associated with Itching:

Itching (4,504 conditions)

Drugs similar to Activella and Itching :

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Activella) and Activella (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.