Actonel and Anasarca - a phase IV clinical study of FDA data

Summary:

Anasarca is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Anasarca when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Anasarca?

Anasarca (general swelling, or massive oedema) is found to be associated with 3,396 drugs and 2,883 conditions by eHealthMe. Check the latest studies of Anasarca.

On Nov, 30, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 511 people (1.77%) have Anasarca.

Among these 511 people:

How long have people been on Actonel when they have Anasarca? *

What is the gender of people who have Anasarca when taking Actonel? *

female: 89.25 %
male: 10.75 %

What is the age of people who have Anasarca when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Anasarca? *

Pain: 300 people, 58.71%
Joint Pain: 220 people, 43.05%
Drug Ineffective: 167 people, 32.68%
Fatigue (feeling of tiredness): 163 people, 31.90%
Joint Swelling: 149 people, 29.16%
Rashes (redness): 147 people, 28.77%
High Blood Pressure: 128 people, 25.05%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 126 people, 24.66%
Pain In Extremity: 124 people, 24.27%
Diarrhea: 122 people, 23.87%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 215 people, 42.07%
Pain: 67 people, 13.11%
High Blood Pressure: 43 people, 8.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 35 people, 6.85%
Metastases To Bone (cancer spreads to bone): 32 people, 6.26%
Multiple Myeloma (cancer of the plasma cells): 26 people, 5.09%
Breast Cancer: 22 people, 4.31%
Fatigue (feeling of tiredness): 20 people, 3.91%
Abdominal Discomfort: 18 people, 3.52%
Parkinson's Disease: 17 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Anasarca?

- Check whether Anasarca is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Anasarca treatments and more:

Anasarca (115,726 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Anasarca:

Browse all the drugs that are associated with Anasarca:

Anasarca (3,396 drugs)

Common conditions associated with Anasarca:

Rheumatoid arthritis: 22,607 reports
Psoriatic arthropathy: 4,468 reports
Hypertension: 3,909 reports
High blood pressure: 3,890 reports
Hbp: 3,886 reports
Pain: 3,785 reports
Pain relief: 3,763 reports
Hypnosis and pain: 3,762 reports
Psoriasis: 3,445 reports
Familial primary pulmonary hypertension: 3,423 reports

Browse all the conditions that are associated with Anasarca:

Anasarca (2,883 conditions)

Drugs similar to Actonel and Anasarca :

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.