Actonel and Chondropathy - a phase IV clinical study of FDA data

Summary:

Chondropathy is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Fosamax, and have Birth control.

The phase IV clinical study analyzes which people have Chondropathy when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Chondropathy?

Chondropathy (disease of the cartilage) is found to be associated with 367 drugs and 434 conditions by eHealthMe. Check the latest studies of Chondropathy.

On Jul, 25, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 37 people (0.13%) have Chondropathy.

Among these 37 people:

How long have people been on Actonel when they have Chondropathy? *

What is the gender of people who have Chondropathy when taking Actonel? *

female: 96.97 %
male: 3.03 %

What is the age of people who have Chondropathy when taking Actonel? *

What are other drugs people take besides Actonel? *

Fosamax: 21 people, 56.76%
Vitamins: 10 people, 27.03%
Trileptal: 7 people, 18.92%
Keppra: 7 people, 18.92%
Plaquenil: 7 people, 18.92%
Paracetamol: 7 people, 18.92%
Alendronate Sodium: 7 people, 18.92%
Methylprednisolone: 3 people, 8.11%
Omega-3 Marine Triglycerides: 3 people, 8.11%
Actemra: 3 people, 8.11%

What are other side effects people have besides Chondropathy? *

Femur Fracture: 23 people, 62.16%
Fall: 22 people, 59.46%
Foot Fracture: 16 people, 43.24%
Radius Fracture: 14 people, 37.84%
Bone Disorder: 14 people, 37.84%
Joint Pain: 13 people, 35.14%
Broken Bone: 11 people, 29.73%
Hot Flush (sudden feelings of heat): 10 people, 27.03%
Ankle Fracture: 10 people, 27.03%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 10 people, 27.03%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 16.22%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 16.22%
Birth Control: 6 people, 16.22%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.81%
Sleep Disorder: 1 person, 2.70%
Prostate Cancer: 1 person, 2.70%
Hypersensitivity: 1 person, 2.70%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 1 person, 2.70%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.70%
Age-Related Macular Degeneration: 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Chondropathy?

- Check whether Chondropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Chondropathy treatments and more:

Chondropathy (3,939 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chondropathy:

Chondropathy (367 drugs)

Browse all the conditions that are associated with Chondropathy:

Chondropathy (434 conditions)

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.