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Actonel and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Fosamax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Ddd when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Ddd?

Ddd is found to be associated with 1,403 drugs and 1,391 conditions by eHealthMe. Check the latest studies of Ddd.

On Nov, 21, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 264 people (0.91%) have Ddd.

Could Actonel cause Ddd?

Among these 264 people:

How long have people been on Actonel when they have Ddd? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 27.56 %
  • 6 - 12 months: 5.51 %
  • 1 - 2 years: 18.11 %
  • 2 - 5 years: 20.47 %
  • 5 - 10 years: 26.77 %
  • 10+ years: 1.57 %

What is the gender of people who have Ddd when taking Actonel? *

  • female: 81.78 %
  • male: 18.22 %

What is the age of people who have Ddd when taking Actonel? *

  • 0-1: 0.0 %
  • 2-9: 0.62 %
  • 10-19: 0.62 %
  • 20-29: 0.0 %
  • 30-39: 1.24 %
  • 40-49: 11.18 %
  • 50-59: 26.09 %
  • 60+: 60.25 %

What are other drugs people take besides Actonel? *

  1. Fosamax: 195 people, 73.86%
  2. Zometa: 48 people, 18.18%
  3. Boniva: 39 people, 14.77%
  4. Synthroid: 36 people, 13.64%
  5. Alendronate Sodium: 35 people, 13.26%
  6. Xanax: 35 people, 13.26%
  7. Aredia: 33 people, 12.50%
  8. Zocor: 29 people, 10.98%
  9. Nexium: 29 people, 10.98%
  10. Lipitor: 26 people, 9.85%

What are other side effects people have besides Ddd? *

  1. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 148 people, 56.06%
  2. Femur Fracture: 124 people, 46.97%
  3. Stress And Anxiety: 116 people, 43.94%
  4. Fall: 114 people, 43.18%
  5. Joint Pain: 112 people, 42.42%
  6. Depression: 87 people, 32.95%
  7. High Blood Pressure: 86 people, 32.58%
  8. Back Pain: 84 people, 31.82%
  9. Intervertebral Disc Protrusion (spinal disc protrusion): 78 people, 29.55%
  10. Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 77 people, 29.17%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 6.82%
  2. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 17 people, 6.44%
  3. High Blood Pressure: 14 people, 5.30%
  4. Neoplasm Malignant (cancer tumour): 8 people, 3.03%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 3.03%
  6. Depression: 7 people, 2.65%
  7. High Blood Cholesterol: 7 people, 2.65%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 2.65%
  9. Stress And Anxiety: 7 people, 2.65%
  10. Asthma: 6 people, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Ddd?

- Check whether Ddd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Ddd treatments and more:

  • Ddd (19,905 reports)

How severe was Ddd and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Actonel side effects:

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ddd:

Browse all the drugs that are associated with Ddd:

  • Ddd (1,403 drugs)

Common conditions associated with Ddd:

Browse all the conditions that are associated with Ddd:

  • Ddd (1,391 conditions)

Drugs similar to Actonel and Ddd :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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