Actonel and Ejection fraction decreased - a phase IV clinical study of FDA data

Summary:

Ejection fraction decreased is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are 60+ old, have been taking the drug for 2 - 5 years also take Omeprazole, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Ejection fraction decreased when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Ejection fraction decreased?

Ejection fraction decreased (systolic heart failure) is found to be associated with 1,066 drugs and 1,252 conditions by eHealthMe. Check the latest studies of Ejection fraction decreased.

On Jul, 12, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 34 people (0.12%) have Ejection fraction decreased.

$Could Actonel cause Ejection fraction decreased?$

Among these 34 people:

How long have people been on Actonel when they have Ejection fraction decreased? *

What is the age of people who have Ejection fraction decreased when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Ejection fraction decreased? *

High Blood Pressure: 14 people, 41.18%
Fall: 13 people, 38.24%
Congestive Cardiomyopathy (weakening of heart muscle): 12 people, 35.29%
Constipation: 11 people, 32.35%
Nausea (feeling of having an urge to vomit): 10 people, 29.41%
Oedema Peripheral (superficial swelling): 10 people, 29.41%
Pain: 10 people, 29.41%
Arrhythmias (irregular heartbeat): 9 people, 26.47%
Cardiac Failure Congestive: 9 people, 26.47%
Diarrhea: 9 people, 26.47%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 20.59%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 20.59%
Fatigue (feeling of tiredness): 6 people, 17.65%
Multiple Myeloma (cancer of the plasma cells): 6 people, 17.65%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 11.76%
Supraventricular Extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle): 4 people, 11.76%
Pain: 3 people, 8.82%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 5.88%
Type 2 Diabetes: 2 people, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Ejection fraction decreased?

- Check whether Ejection fraction decreased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ejection fraction decreased:

Ejection fraction decreased (1,066 drugs)

Browse all the conditions that are associated with Ejection fraction decreased:

Ejection fraction decreased (1,252 conditions)

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.