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Actonel and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Fosamax, and have High blood pressure.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 903 drugs and 792 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On Feb, 07, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 36 people (0.12%) have Left ventricular dysfunction.

Could Actonel cause Left ventricular dysfunction?

Among these 36 people:

How long have people been on Actonel when they have Left ventricular dysfunction? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 7.69 %
  • 6 - 12 months: 69.23 %
  • 1 - 2 years: 7.69 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 15.38 %
  • 10+ years: 0.0 %

What is the gender of people who have Left ventricular dysfunction when taking Actonel? *

  • female: 77.78 %
  • male: 22.22 %

What is the age of people who have Left ventricular dysfunction when taking Actonel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 24.24 %
  • 60+: 75.76 %

What are other drugs people take besides Actonel? *

  1. Fosamax: 19 people, 52.78%
  2. Coumadin: 15 people, 41.67%
  3. Prednisone: 14 people, 38.89%
  4. Norvasc: 13 people, 36.11%
  5. Lasix: 11 people, 30.56%
  6. Nexium: 11 people, 30.56%
  7. Furosemide: 11 people, 30.56%
  8. Premarin: 10 people, 27.78%
  9. Neulasta: 10 people, 27.78%
  10. Aranesp: 10 people, 27.78%

What are other side effects people have besides Left ventricular dysfunction? *

  1. Pain: 28 people, 77.78%
  2. Stress And Anxiety: 27 people, 75.00%
  3. Head Injury: 26 people, 72.22%
  4. Weakness: 25 people, 69.44%
  5. Back Pain: 23 people, 63.89%
  6. Fall: 23 people, 63.89%
  7. Cardiac Failure Congestive: 22 people, 61.11%
  8. Osteonecrosis Of Jaw (death of bone of jaw): 22 people, 61.11%
  9. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 22 people, 61.11%
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 21 people, 58.33%

What are the existing conditions these people have? *

  1. High Blood Pressure: 10 people, 27.78%
  2. Abdominal Discomfort: 7 people, 19.44%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.11%
  4. Klebsiella Infection: 4 people, 11.11%
  5. Cardiac Failure Congestive: 3 people, 8.33%
  6. Oesophageal Carcinoma (cancer tumour of oesophagus): 1 person, 2.78%
  7. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 2.78%
  8. Multiple Myeloma (cancer of the plasma cells): 1 person, 2.78%
  9. Metastases To Bone (cancer spreads to bone): 1 person, 2.78%
  10. Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Left ventricular dysfunction treatments and more:

How severe was Left ventricular dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Browse all the conditions that are associated with Left ventricular dysfunction:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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