Actonel and Lyme disease - a phase IV clinical study of FDA data

Summary:

Lyme disease is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Lyme disease when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Lyme disease?

Lyme disease (a bacterial infection that is spread to humans by infected ticks) is found to be associated with 430 drugs and 620 conditions by eHealthMe. Check the latest studies of Lyme disease.

On Jul, 29, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 12 people (0.04%) have Lyme disease.

Among these 12 people:

How long have people been on Actonel when they have Lyme disease? *

What is the gender of people who have Lyme disease when taking Actonel? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Lyme disease when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Lyme disease? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 75.00%
Osteonecrosis Of Jaw (death of bone of jaw): 8 people, 66.67%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 8 people, 66.67%
Adverse Drug Reaction: 7 people, 58.33%
Drug Hypersensitivity: 7 people, 58.33%
Joint Pain: 6 people, 50.00%
Intervertebral Disc Protrusion (spinal disc protrusion): 6 people, 50.00%
Infection: 6 people, 50.00%
Spinal Column Stenosis (narrowing of spinal column): 6 people, 50.00%
Rib Fracture: 5 people, 41.67%

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 33.33%
High Blood Cholesterol: 4 people, 33.33%
Vomiting In Pregnancy: 1 person, 8.33%
Thrombosis (formation of a blood clot inside a blood vessel): 1 person, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Quit Smoking: 1 person, 8.33%
Prostate Cancer: 1 person, 8.33%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 1 person, 8.33%
Hypersensitivity: 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Lyme disease?

- Check whether Lyme disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Lyme disease treatments and more:

Lyme disease (6,357 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lyme disease:

Lyme disease (430 drugs)

Browse all the conditions that are associated with Lyme disease:

Lyme disease (620 conditions)

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.