Actonel and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Fosamax, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Mental status changes when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,528 drugs and 1,740 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Nov, 02, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 93 people (0.32%) have Mental status changes.

Could Actonel cause Mental status changes?

Among these 93 people:

How long have people been on Actonel when they have Mental status changes? *

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What is the gender of people who have Mental status changes when taking Actonel? *

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* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Mental status changes?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Mental status changes treatments and more:

Mental status changes (32,338 reports)

How severe was Mental status changes and when was it recovered:

Mental status changes in Actonel

Expand to all the drugs that have ingredients of risedronate sodium:

Mental status changes and drugs with ingredients of risedronate sodium

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Actonel side effects:

Actonel side effect: Fall (2,644 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Mental status changes:

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,528 drugs)

Common conditions associated with Mental status changes:

Pain: 1,930 reports
Alternative medicine - pain relief: 1,897 reports
Acupuncture and pain: 1,306 reports
Depression: 1,243 reports
Antidepressant therapy: 1,229 reports
Hypertension: 1,164 reports
Blood pressure - high: 1,149 reports
Plasma cell myeloma: 1,050 reports
Multiple sclerosis: 899 reports
Anxiety aggravated: 747 reports

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,740 conditions)

Drugs similar to Actonel and Mental status changes :

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.