Actonel and Plmd - a phase IV clinical study of FDA data

Summary:

Plmd is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Plmd when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Plmd?

Plmd is found to be associated with 2,194 drugs and 1,888 conditions by eHealthMe. Check the latest studies of Plmd.

On Oct, 15, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 108 people (0.37%) have Plmd.

Among these 108 people:

How long have people been on Actonel when they have Plmd? *

What is the gender of people who have Plmd when taking Actonel? *

female: 91.35 %
male: 8.65 %

What is the age of people who have Plmd when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Plmd? *

Stress And Anxiety: 62 people, 57.41%
Fall: 62 people, 57.41%
Depression: 50 people, 46.30%
High Blood Pressure: 44 people, 40.74%
Rashes (redness): 43 people, 39.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 43 people, 39.81%
Osteonecrosis Of Jaw (death of bone of jaw): 41 people, 37.96%
Pain: 40 people, 37.04%
Diarrhea: 37 people, 34.26%
Chest Pain: 37 people, 34.26%

What are the existing conditions these people have? *

Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 13 people, 12.04%
Lung Cancer - Non-Small Cell (lung cancer): 13 people, 12.04%
High Blood Pressure: 9 people, 8.33%
High Blood Cholesterol: 7 people, 6.48%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 5.56%
Hypersensitivity: 5 people, 4.63%
Depression: 5 people, 4.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 4.63%
Pain: 5 people, 4.63%
Mitral Valve Prolapse (heart's mitral valve doesn't work well): 4 people, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Plmd?

- Check whether Plmd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Plmd treatments and more:

Plmd (49,958 reports)

Common Actonel side effects:

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Plmd:

Browse all the drugs that are associated with Plmd:

Plmd (2,194 drugs)

Common conditions associated with Plmd:

Depression aggravated: 1,745 reports
Rls: 1,513 reports
Restless legs syndrome: 1,450 reports
Multiple sclerosis: 1,176 reports
Periodic limb movement disorder: 1,066 reports
Pain: 1,043 reports
Pain relief: 1,041 reports
Narcolepsy: 983 reports
Osteoporosis: 960 reports
Thin bones: 927 reports

Browse all the conditions that are associated with Plmd:

Plmd (1,888 conditions)

Drugs similar to Actonel and Plmd :

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.