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Actonel and Sciatic nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Sciatic nerve dysfunction is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Fosamax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sciatic nerve dysfunction when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Sciatic nerve dysfunction?

Sciatic nerve dysfunction (a condition in which the sciatic nerve conducts impulses abnormally) is found to be associated with 1,826 drugs and 1,461 conditions by eHealthMe. Check the latest studies of Sciatic nerve dysfunction.

On Jun, 18, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 152 people (0.53%) have Sciatic nerve dysfunction.

Could Actonel cause Sciatic nerve dysfunction?

Among these 152 people:

How long have people been on Actonel when they have Sciatic nerve dysfunction? *

  • < 1 month: 5.77 %
  • 1 - 6 months: 26.92 %
  • 6 - 12 months: 5.77 %
  • 1 - 2 years: 32.69 %
  • 2 - 5 years: 17.31 %
  • 5 - 10 years: 5.77 %
  • 10+ years: 5.77 %

What is the gender of people who have Sciatic nerve dysfunction when taking Actonel? *

  • female: 85.61 %
  • male: 14.39 %

What is the age of people who have Sciatic nerve dysfunction when taking Actonel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5.21 %
  • 40-49: 5.21 %
  • 50-59: 27.08 %
  • 60+: 62.5 %

What are other drugs people take besides Actonel? *

  1. Fosamax: 70 people, 46.05%
  2. Alendronate Sodium: 30 people, 19.74%
  3. Zometa: 21 people, 13.82%
  4. Lyrica: 20 people, 13.16%
  5. Prednisone: 20 people, 13.16%
  6. Xanax: 18 people, 11.84%
  7. Celebrex: 15 people, 9.87%
  8. Synthroid: 15 people, 9.87%
  9. Vitamins: 15 people, 9.87%
  10. Vicodin: 14 people, 9.21%

What are other side effects people have besides Sciatic nerve dysfunction? *

  1. Femur Fracture: 63 people, 41.45%
  2. Joint Pain: 59 people, 38.82%
  3. Back Pain: 57 people, 37.50%
  4. Pain: 56 people, 36.84%
  5. High Blood Pressure: 54 people, 35.53%
  6. Fall: 54 people, 35.53%
  7. Pain In Extremity: 50 people, 32.89%
  8. Intervertebral Disc Protrusion (spinal disc protrusion): 41 people, 26.97%
  9. High Blood Cholesterol: 39 people, 25.66%
  10. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 38 people, 25.00%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 26 people, 17.11%
  2. High Blood Pressure: 7 people, 4.61%
  3. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 7 people, 4.61%
  4. Thyroid Diseases: 5 people, 3.29%
  5. Type 2 Diabetes: 5 people, 3.29%
  6. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 2.63%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 2.63%
  8. Prostate Cancer: 4 people, 2.63%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 2.63%
  10. Depression: 3 people, 1.97%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Sciatic nerve dysfunction?

- Check whether Sciatic nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Sciatic nerve dysfunction treatments and more:

How severe was Sciatic nerve dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatic nerve dysfunction:

Browse all the conditions that are associated with Sciatic nerve dysfunction:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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