Actonel and Skin tightness - a phase IV clinical study of FDA data

Summary:

Skin tightness is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Diflucan, and have Depression.

The phase IV clinical study analyzes which people have Skin tightness when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Skin tightness?

Skin tightness is found to be associated with 616 drugs and 605 conditions by eHealthMe. Check the latest studies of Skin tightness.

On Jul, 08, 2026

28,929 people reported to have side effects when taking Actonel.
Among them, 24 people (0.08%) have Skin tightness.

Among these 24 people:

How long have people been on Actonel when they have Skin tightness? *

What is the gender of people who have Skin tightness when taking Actonel? *

female: 36.36 %
male: 63.64 %

What is the age of people who have Skin tightness when taking Actonel? *

What are other drugs people take besides Actonel? *

What are other side effects people have besides Skin tightness? *

Joint Pain: 15 people, 62.50%
Pain: 14 people, 58.33%
Weakness: 14 people, 58.33%
Fatigue (feeling of tiredness): 13 people, 54.17%
Stress And Anxiety: 13 people, 54.17%
Rashes (redness): 12 people, 50.00%
Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 12 people, 50.00%
Oedema Peripheral (superficial swelling): 12 people, 50.00%
Mobility Decreased (ability to move is reduced): 12 people, 50.00%
Joint Stiffness: 11 people, 45.83%

What are the existing conditions these people have? *

Depression: 10 people, 41.67%
Polymyalgia Rheumatica (pain in many muscles): 9 people, 37.50%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 9 people, 37.50%
Anaemia (lack of blood): 9 people, 37.50%
Nuclear Magnetic Resonance Imaging Brain: 5 people, 20.83%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 4 people, 16.67%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 4 people, 16.67%
Interstitial Lung Disease: 4 people, 16.67%
Upper Respiratory Tract Infection: 2 people, 8.33%
Renal Disorder (kidney disease): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Skin tightness?

- Check whether Skin tightness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Actonel (29,369 reports)

Skin tightness treatments and more:

Skin tightness (5,694 reports)

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin tightness:

Skin tightness (616 drugs)

Browse all the conditions that are associated with Skin tightness:

Skin tightness (605 conditions)

Related publications that referenced our studies

Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .
Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A, "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", Clinical schizophrenia & related psychoses, 2013 May .
Ko KD, Cho BL, "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", Journal of the Korean Geriatrics Society, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.