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Actonel and Under active thyroids - a phase IV clinical study of FDA data

Summary:

Under active thyroids is reported as a side effect among people who take Actonel (risedronate sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Under active thyroids when taking Actonel. It is created by eHealthMe based on reports of 28,929 people who have side effects when taking Actonel from the FDA, and is updated regularly.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

What is Under active thyroids?

Under active thyroids is found to be associated with 2,712 drugs and 2,595 conditions by eHealthMe. Check the latest studies of Under active thyroids.

On Oct, 13, 2025

28,929 people reported to have side effects when taking Actonel.
Among them, 315 people (1.09%) have Under active thyroids.

Could Actonel cause Under active thyroids?

Among these 315 people:

How long have people been on Actonel when they have Under active thyroids? *

  • < 1 month: 2.27 %
  • 1 - 6 months: 22.73 %
  • 6 - 12 months: 11.36 %
  • 1 - 2 years: 12.12 %
  • 2 - 5 years: 34.09 %
  • 5 - 10 years: 15.15 %
  • 10+ years: 2.27 %

What is the gender of people who have Under active thyroids when taking Actonel? *

  • female: 92.86 %
  • male: 7.14 %

What is the age of people who have Under active thyroids when taking Actonel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.5 %
  • 30-39: 1.0 %
  • 40-49: 24.38 %
  • 50-59: 22.89 %
  • 60+: 51.24 %

What are other drugs people take besides Actonel? *

  1. Fosamax: 189 people, 60.00%
  2. Synthroid: 51 people, 16.19%
  3. Alendronate Sodium: 41 people, 13.02%
  4. Boniva: 34 people, 10.79%
  5. Enbrel: 34 people, 10.79%
  6. Prednisone: 29 people, 9.21%
  7. Tylenol: 28 people, 8.89%
  8. Fosamax Plus D: 25 people, 7.94%
  9. Vitamin B12: 23 people, 7.30%
  10. Xeljanz: 23 people, 7.30%

What are other side effects people have besides Under active thyroids? *

  1. Femur Fracture: 140 people, 44.44%
  2. Fall: 132 people, 41.90%
  3. High Blood Pressure: 131 people, 41.59%
  4. Joint Pain: 103 people, 32.70%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 101 people, 32.06%
  6. Depression: 101 people, 32.06%
  7. Anaemia (lack of blood): 92 people, 29.21%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 90 people, 28.57%
  9. High Blood Cholesterol: 86 people, 27.30%
  10. Urinary Tract Infection: 84 people, 26.67%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 46 people, 14.60%
  2. High Blood Pressure: 25 people, 7.94%
  3. Pain: 24 people, 7.62%
  4. Depression: 19 people, 6.03%
  5. High Blood Cholesterol: 15 people, 4.76%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 13 people, 4.13%
  7. Stress And Anxiety: 10 people, 3.17%
  8. Breast Cancer: 10 people, 3.17%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 3.17%
  10. Sleep Disorder: 8 people, 2.54%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Under active thyroids?

- Check whether Under active thyroids is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actonel:

Under active thyroids treatments and more:

How severe was Under active thyroids and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Actonel side effects:

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Under active thyroids:

Browse all the drugs that are associated with Under active thyroids:

Common conditions associated with Under active thyroids:

Browse all the conditions that are associated with Under active thyroids:

Drugs similar to Actonel and Under active thyroids :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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