Actoplus met and Hypotension - a phase IV clinical study of FDA data

Summary:

Hypotension is reported as a side effect among people who take Actoplus met (metformin hydrochloride; pioglitazone hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Januvia, and have Autonomic failure syndrome.

The phase IV clinical study analyzes which people have Hypotension when taking Actoplus met. It is created by eHealthMe based on reports of 1,111 people who have side effects when taking Actoplus met from the FDA, and is updated regularly.

What is Actoplus met?

Actoplus met has active ingredients of metformin hydrochloride; pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,210 Actoplus met users. Check the latest studies of Actoplus met.

What is Hypotension?

Hypotension (abnormally low blood pressure) is found to be associated with 3,354 drugs and 4,759 conditions by eHealthMe. Check the latest studies of Hypotension.

On Aug, 05, 2026

1,111 people reported to have side effects when taking Actoplus met.
Among them, 13 people (1.17%) have Hypotension.

Among these 13 people:

How long have people been on Actoplus met when they have Hypotension? *

What is the gender of people who have Hypotension when taking Actoplus met? *

female: 23.08 %
male: 76.92 %

What is the age of people who have Hypotension when taking Actoplus met? *

What are other drugs people take besides Actoplus met? *

What are other side effects people have besides Hypotension? *

Nausea (feeling of having an urge to vomit): 5 people, 38.46%
Dizziness: 5 people, 38.46%
Anaemia (lack of blood): 5 people, 38.46%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 4 people, 30.77%
Fall: 4 people, 30.77%
Abdominal Pain: 4 people, 30.77%
Hepatic Lesion: 4 people, 30.77%
Back Pain: 4 people, 30.77%
Dehydration (dryness resulting from the removal of water): 4 people, 30.77%
Erection Problems: 4 people, 30.77%

What are the existing conditions these people have? *

Parkinson's Disease: 1 person, 7.69%
Pain: 1 person, 7.69%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 7.69%
Neuralgia (pain in one or more nerves): 1 person, 7.69%
Headache (pain in head): 1 person, 7.69%
Autonomic Failure Syndrome (a degenerative disease of the autonomic nervous system): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Actoplus met and have Hypotension?

- Check whether Hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actoplus met:

Actoplus met (1,210 reports)

Hypotension treatments and more:

Hypotension (329,856 reports)

How severe was Hypotension and when was it recovered:

Hypotension in Actoplus met

Expand to all the drugs that have ingredients of metformin hydrochloride; pioglitazone hydrochloride:

Hypotension and drugs with ingredients of metformin hydrochloride; pioglitazone hydrochloride (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actoplus met:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypotension:

Hypotension (3,354 drugs)

Browse all the conditions that are associated with Hypotension:

Hypotension (4,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride; pioglitazone hydrochloride (the active ingredients of Actoplus met) and Actoplus met (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.