Actoplus met and Nausea and vomiting - a phase IV clinical study of FDA data

Summary:

Nausea and vomiting is reported as a side effect among people who take Actoplus met (metformin hydrochloride; pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Byetta, and have Neuropathy peripheral.

The phase IV clinical study analyzes which people have Nausea and vomiting when taking Actoplus met. It is created by eHealthMe based on reports of 1,111 people who have side effects when taking Actoplus met from the FDA, and is updated regularly.

What is Actoplus met?

Actoplus met has active ingredients of metformin hydrochloride; pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,210 Actoplus met users. Check the latest studies of Actoplus met.

What is Nausea and vomiting?

Nausea and vomiting is found to be associated with 3,711 drugs and 5,746 conditions by eHealthMe. Check the latest studies of Nausea and vomiting.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

1,111 people reported to have side effects when taking Actoplus met.
Among them, 37 people (3.33%) have Nausea and vomiting.

Could Actoplus met cause Nausea and vomiting?

Among these 37 people:

How long have people been on Actoplus met when they have Nausea and vomiting? *

What is the gender of people who have Nausea and vomiting when taking Actoplus met? *

female: 67.57 %
male: 32.43 %

What is the age of people who have Nausea and vomiting when taking Actoplus met? *

What are other drugs people take besides Actoplus met? *

What are other side effects people have besides Nausea and vomiting? *

Nausea (feeling of having an urge to vomit): 28 people, 75.68%
Diarrhea: 9 people, 24.32%
Weight Decreased: 8 people, 21.62%
Abdominal Pain Upper: 7 people, 18.92%
Belching (release of gas from the digestive tract): 7 people, 18.92%
Weakness: 5 people, 13.51%
Cough: 4 people, 10.81%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 10.81%
Dizziness: 4 people, 10.81%
Pancreatitis (inflammation of pancreas): 4 people, 10.81%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 8.11%
Pain: 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.11%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 8.11%
Neuropathy Peripheral (surface nerve damage): 3 people, 8.11%
Itching: 2 people, 5.41%
Vulvovaginal Mycotic Infection (vulvovaginal fungal infection): 2 people, 5.41%
Gastric Disorder (disease of stomach): 2 people, 5.41%
Cough: 2 people, 5.41%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Actoplus met and have Nausea and vomiting?

- Check whether Nausea and vomiting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actoplus met:

Actoplus met (1,210 reports)

Nausea and vomiting treatments and more:

Nausea and vomiting (529,396 reports)

How severe was Nausea and vomiting and when was it recovered:

Nausea and vomiting in Actoplus met

Expand to all the drugs that have ingredients of metformin hydrochloride; pioglitazone hydrochloride:

Nausea and vomiting and drugs with ingredients of metformin hydrochloride; pioglitazone hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actoplus met:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nausea and vomiting:

Nausea and vomiting (3,711 drugs)

Browse all the conditions that are associated with Nausea and vomiting:

Nausea and vomiting (5,746 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride; pioglitazone hydrochloride (the active ingredients of Actoplus met) and Actoplus met (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.