Actos and Heart valve surgery - a phase IV clinical study of FDA data

Summary:

Heart valve surgery is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Synthroid, and have Cataplexy.

The phase IV clinical study analyzes which people have Heart valve surgery when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Heart valve surgery?

Heart valve surgery is found to be associated with 160 drugs and 436 conditions by eHealthMe. Check the latest studies of Heart valve surgery.

On May, 10, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 12 people (0.02%) have Heart valve surgery.

Among these 12 people:

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Heart valve surgery?

- Check whether Heart valve surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Heart valve surgery treatments and more:

Heart valve surgery (3,421 reports)

How severe was Heart valve surgery and when was it recovered:

Heart valve surgery in Actos

Expand to all the drugs that have ingredients of pioglitazone hydrochloride:

Heart valve surgery and drugs with ingredients of pioglitazone hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart valve surgery:

Heart valve surgery (160 drugs)

Browse all the conditions that are associated with Heart valve surgery:

Heart valve surgery (436 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.