Actos and Impaired work ability - a phase IV clinical study of FDA data

Summary:

Impaired work ability is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Glucophage, and have Migraine.

The phase IV clinical study analyzes which people have Impaired work ability when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Impaired work ability?

Impaired work ability is found to be associated with 1,015 drugs and 1,137 conditions by eHealthMe. Check the latest studies of Impaired work ability.

On Jul, 11, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 30 people (0.06%) have Impaired work ability.

Could Actos cause Impaired work ability?

Among these 30 people:

How long have people been on Actos when they have Impaired work ability? *

What is the gender of people who have Impaired work ability when taking Actos? *

female: 63.33 %
male: 36.67 %

What is the age of people who have Impaired work ability when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Impaired work ability? *

Depression: 10 people, 33.33%
Weight Increased: 8 people, 26.67%
Dizziness: 7 people, 23.33%
Nausea (feeling of having an urge to vomit): 7 people, 23.33%
Chest Pain: 6 people, 20.00%
Stress And Anxiety: 6 people, 20.00%
Gait Disturbance: 6 people, 20.00%
High Blood Pressure: 6 people, 20.00%
Dyspnea (difficult or laboured breathing): 6 people, 20.00%
Joint Pain: 6 people, 20.00%

What are the existing conditions these people have? *

Migraine (headache): 5 people, 16.67%
Quit Smoking: 4 people, 13.33%
Depression: 4 people, 13.33%
Stress And Anxiety: 2 people, 6.67%
Pain: 2 people, 6.67%
Cardiac Disorder: 2 people, 6.67%
Skin Ulcer: 1 person, 3.33%
Peripheral Neuropathy (damage to nerves of the peripheral nervous system): 1 person, 3.33%
Nasopharyngitis (inflammation of the nasopharynx): 1 person, 3.33%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Impaired work ability?

- Check whether Impaired work ability is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Impaired work ability:

Impaired work ability (1,015 drugs)

Browse all the conditions that are associated with Impaired work ability:

Impaired work ability (1,137 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.