Actos and Ipf - a phase IV clinical study of FDA data

Summary:

Ipf is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Lasix, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Ipf when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Ipf?

Ipf is found to be associated with 1,805 drugs and 2,276 conditions by eHealthMe. Check the latest studies of Ipf.

On Jun, 18, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 82 people (0.17%) have Ipf.

Among these 82 people:

How long have people been on Actos when they have Ipf? *

What is the gender of people who have Ipf when taking Actos? *

female: 27.5 %
male: 72.5 %

What is the age of people who have Ipf when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Ipf? *

Dyspnea (difficult or laboured breathing): 32 people, 39.02%
Pain: 27 people, 32.93%
Chest Pain: 26 people, 31.71%
Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 29.27%
Sinusitis (inflammation of sinus): 23 people, 28.05%
Constipation: 22 people, 26.83%
Insomnia (sleeplessness): 22 people, 26.83%
Pleural Effusion (water on the lungs): 22 people, 26.83%
Cardiac Failure Congestive: 21 people, 25.61%
Interstitial Lung Disease: 21 people, 25.61%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 10 people, 12.20%
High Blood Pressure: 5 people, 6.10%
Depression: 4 people, 4.88%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 4.88%
Stable Angina (a constant chest pain): 3 people, 3.66%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 3.66%
Multiple Myeloma (cancer of the plasma cells): 3 people, 3.66%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 2.44%
Blood Viscosity Increased: 2 people, 2.44%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Ipf?

- Check whether Ipf is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Ipf treatments and more:

Ipf (79,193 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ipf:

Ipf (1,805 drugs)

Browse all the conditions that are associated with Ipf:

Ipf (2,276 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.