Actos and Listless - a phase IV clinical study of FDA data

Summary:

Listless is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metoprolol Tartrate, and have High blood pressure.

The phase IV clinical study analyzes which people have Listless when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Listless?

Listless (lack of interest, energy, or spirit) is found to be associated with 459 drugs and 653 conditions by eHealthMe. Check the latest studies of Listless.

On Jul, 20, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 14 people (0.03%) have Listless.

Among these 14 people:

How long have people been on Actos when they have Listless? *

What is the gender of people who have Listless when taking Actos? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Listless when taking Actos? *

What are other drugs people take besides Actos? *

Diovan: 3 people, 21.43%
Lisinopril: 3 people, 21.43%
Metoprolol Tartrate: 3 people, 21.43%
Clonidine: 2 people, 14.29%
Glipizide: 2 people, 14.29%
Hydrochlorothiazide: 2 people, 14.29%
Lipitor: 2 people, 14.29%
Metformin Hydrochloride: 2 people, 14.29%
Synthroid: 2 people, 14.29%
Simvastatin: 2 people, 14.29%

What are other side effects people have besides Listless? *

Feeling Abnormal: 4 people, 28.57%
Fatigue (feeling of tiredness): 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Vision Blurred: 3 people, 21.43%
Cardiac Failure: 2 people, 14.29%
Heart Rate Increased: 2 people, 14.29%
Lobar Pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung): 2 people, 14.29%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 14.29%
Dizziness: 2 people, 14.29%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 14.29%

What are the existing conditions these people have? *

High Blood Pressure: 2 people, 14.29%
Hepatitis C: 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%
Chronic Renal Failure (kidney failure): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Listless?

- Check whether Listless is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,754 reports)

Listless treatments and more:

Listless (4,524 reports)

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Listless:

Listless (459 drugs)

Browse all the conditions that are associated with Listless:

Listless (653 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.