Actos and Sleeping difficulty - a phase IV clinical study of FDA data

Summary:

Sleeping difficulty is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lipitor, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Sleeping difficulty when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,753 Actos users. Check the latest studies of Actos.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,237 drugs and 5,349 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.

On Nov, 07, 2025

49,087 people reported to have side effects when taking Actos.
Among them, 711 people (1.45%) have Sleeping difficulty.

Among these 711 people:

How long have people been on Actos when they have Sleeping difficulty? *

What is the gender of people who have Sleeping difficulty when taking Actos? *

female: 53.61 %
male: 46.39 %

What is the age of people who have Sleeping difficulty when taking Actos? *

What are other drugs people take besides Actos? *

What are other side effects people have besides Sleeping difficulty? *

Stress And Anxiety: 201 people, 28.27%
Nausea (feeling of having an urge to vomit): 199 people, 27.99%
Pain: 184 people, 25.88%
Fatigue (feeling of tiredness): 151 people, 21.24%
Chest Pain: 150 people, 21.10%
Dizziness: 137 people, 19.27%
Weakness: 137 people, 19.27%
Headache (pain in head): 137 people, 19.27%
Depression: 136 people, 19.13%
Dyspnea (difficult or laboured breathing): 132 people, 18.57%

What are the existing conditions these people have? *

High Blood Cholesterol: 89 people, 12.52%
High Blood Pressure: 74 people, 10.41%
Depression: 51 people, 7.17%
Pain: 47 people, 6.61%
Stress And Anxiety: 39 people, 5.49%
Bipolar Disorder (mood disorder): 30 people, 4.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 27 people, 3.80%
Quit Smoking: 26 people, 3.66%
Multiple Myeloma (cancer of the plasma cells): 25 people, 3.52%
Osteoporosis (bones weak and more likely to break): 24 people, 3.38%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Sleeping difficulty?

- Check whether Sleeping difficulty is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Actos (49,753 reports)

Common Actos side effects:

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sleeping difficulty:

Browse all the drugs that are associated with Sleeping difficulty:

Sleeping difficulty (4,237 drugs)

Common conditions associated with Sleeping difficulty:

Depression aggravated: 17,540 reports
Antidepressant therapy: 17,500 reports
Pain exacerbated: 13,668 reports
Rheumatoid arthritis aggravated: 13,625 reports
Hypnosis and pain: 13,485 reports
Ms: 12,998 reports
Hypertension: 12,107 reports
Hbp: 12,061 reports
Anxiety: 10,449 reports
Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 10,431 reports

Browse all the conditions that are associated with Sleeping difficulty:

Sleeping difficulty (5,349 conditions)

Drugs similar to Actos and Sleeping difficulty :

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.