1. Home
  2. Analysis
  3. Actos
  4. Sluggishness

Actos and Sluggishness - a phase IV clinical study of FDA data

Summary:

Sluggishness is reported as a side effect among people who take Actos (pioglitazone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Byetta, and have Chest pain.

The phase IV clinical study analyzes which people have Sluggishness when taking Actos. It is created by eHealthMe based on reports of 49,087 people who have side effects when taking Actos from the FDA, and is updated regularly.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

What is Sluggishness?

Sluggishness (lacking alertness) is found to be associated with 832 drugs and 744 conditions by eHealthMe. Check the latest studies of Sluggishness.

On Apr, 18, 2026

49,087 people reported to have side effects when taking Actos.
Among them, 19 people (0.04%) have Sluggishness.

Could Actos cause Sluggishness?

Among these 19 people:

How long have people been on Actos when they have Sluggishness? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the gender of people who have Sluggishness when taking Actos? *

  • female: 38.89 %
  • male: 61.11 %

What is the age of people who have Sluggishness when taking Actos? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.25 %
  • 40-49: 18.75 %
  • 50-59: 18.75 %
  • 60+: 56.25 %

What are other drugs people take besides Actos? *

  1. Byetta: 10 people, 52.63%
  2. Humalog: 3 people, 15.79%
  3. Amaryl: 3 people, 15.79%
  4. Lipitor: 3 people, 15.79%
  5. Furosemide: 3 people, 15.79%
  6. Albuterol: 2 people, 10.53%
  7. Glucotrol Xl: 2 people, 10.53%
  8. Zaroxolyn: 2 people, 10.53%
  9. Flomax: 2 people, 10.53%
  10. Effexor: 2 people, 10.53%

What are other side effects people have besides Sluggishness? *

  1. Blood Glucose Increased: 6 people, 31.58%
  2. Headache (pain in head): 5 people, 26.32%
  3. Fatigue (feeling of tiredness): 5 people, 26.32%
  4. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 21.05%
  5. Diarrhea: 4 people, 21.05%
  6. Blood Glucose Decreased: 4 people, 21.05%
  7. Fall: 3 people, 15.79%
  8. Muscle Aches (muscle pain): 3 people, 15.79%
  9. Malaise (a feeling of general discomfort or uneasiness): 3 people, 15.79%
  10. Drug Ineffective: 3 people, 15.79%

What are the existing conditions these people have? *

  1. Cough: 2 people, 10.53%
  2. Chest Pain: 2 people, 10.53%
  3. Sinus Disorder (disease of sinus): 1 person, 5.26%
  4. Pulmonary Congestion (congestion in the lungs): 1 person, 5.26%
  5. Pneumococcal Infection (infection caused by streptococcus pneumoniae): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Sluggishness?

- Check whether Sluggishness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actos:

Sluggishness treatments and more:

How severe was Sluggishness and when was it recovered:

Expand to all the drugs that have ingredients of pioglitazone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sluggishness:

Browse all the conditions that are associated with Sluggishness:

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.