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Actrapid and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Actrapid (insulin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Metformin, and have High blood pressure.

The phase IV clinical study analyzes which people have Hyponatremia when taking Actrapid. It is created by eHealthMe based on reports of 4,843 people who have side effects when taking Actrapid from the FDA, and is updated regularly.

What is Actrapid?

Actrapid has active ingredients of insulin. eHealthMe is studying from 4,864 Actrapid users. Check the latest studies of Actrapid.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,940 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Jul, 18, 2026

4,843 people reported to have side effects when taking Actrapid.
Among them, 54 people (1.12%) have Hyponatremia.

Could Actrapid cause Hyponatremia?

Among these 54 people:

How long have people been on Actrapid when they have Hyponatremia? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Actrapid? *

  • female: 48.15 %
  • male: 51.85 %

What is the age of people who have Hyponatremia when taking Actrapid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.55 %
  • 30-39: 1.89 %
  • 40-49: 9.43 %
  • 50-59: 20.75 %
  • 60+: 60.38 %

What are other drugs people take besides Actrapid? *

  1. Aspirin: 14 people, 25.93%
  2. Metformin: 14 people, 25.93%
  3. Simvastatin: 12 people, 22.22%
  4. Morphine: 12 people, 22.22%
  5. Zyprexa: 11 people, 20.37%
  6. Amlodipine Besylate: 11 people, 20.37%
  7. Docetaxel: 11 people, 20.37%
  8. Nintedanib: 11 people, 20.37%
  9. Cymbalta: 8 people, 14.81%
  10. Nexium: 8 people, 14.81%

What are other side effects people have besides Hyponatremia? *

  1. Anaemia (lack of blood): 16 people, 29.63%
  2. Diarrhea: 14 people, 25.93%
  3. Oesophagitis (inflammation of oesophagus): 11 people, 20.37%
  4. Pneumonia: 11 people, 20.37%
  5. Hypokalemia (low potassium): 9 people, 16.67%
  6. Electrocardiogram Qt Prolonged: 8 people, 14.81%
  7. Thrombocytopenia (decrease of platelets in blood): 8 people, 14.81%
  8. Dizziness: 8 people, 14.81%
  9. Fall: 8 people, 14.81%
  10. Fainting (loss of consciousness and postural tone): 7 people, 12.96%

What are the existing conditions these people have? *

  1. High Blood Pressure: 18 people, 33.33%
  2. Diabetes: 14 people, 25.93%
  3. Dyspnea (difficult or laboured breathing): 12 people, 22.22%
  4. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 11 people, 20.37%
  5. Lung Adenocarcinoma (a form of non-small cell lung cancer): 11 people, 20.37%
  6. Oesophagitis (inflammation of oesophagus): 9 people, 16.67%
  7. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 9.26%
  8. Depression: 4 people, 7.41%
  9. Type 1 Diabetes: 3 people, 5.56%
  10. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Actrapid and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Actrapid:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of insulin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Actrapid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on insulin (the active ingredients of Actrapid) and Actrapid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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