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Acyclovir and Acanthamoeba infection - a phase IV clinical study of FDA data

Summary:

Acanthamoeba infection is reported as a side effect among people who take Acyclovir (acyclovir), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Tacrolimus, and have Acute graft versus host disease.

The phase IV clinical study analyzes which people have Acanthamoeba infection when taking Acyclovir. It is created by eHealthMe based on reports of 53,484 people who have side effects when taking Acyclovir from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Acanthamoeba infection?

Acanthamoeba infection (acanthamoeba infection is a cutaneous condition) is found to be associated with 25 drugs and 53 conditions by eHealthMe. Check the latest studies of Acanthamoeba infection.

On Aug, 04, 2026

53,484 people reported to have side effects when taking Acyclovir.
Among them, 13 people (0.02%) have Acanthamoeba infection.

Could Acyclovir cause Acanthamoeba infection?

Among these 13 people:

How long have people been on Acyclovir when they have Acanthamoeba infection? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Acanthamoeba infection when taking Acyclovir? *

  • female: 15.38 %
  • male: 84.62 %

What is the age of people who have Acanthamoeba infection when taking Acyclovir? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.69 %
  • 30-39: 15.38 %
  • 40-49: 0.0 %
  • 50-59: 15.38 %
  • 60+: 61.54 %

What are other drugs people take besides Acyclovir? *

  1. Tacrolimus: 10 people, 76.92%
  2. Pentamidine Isethionate: 7 people, 53.85%
  3. Methylprednisolone: 7 people, 53.85%
  4. Fluconazole: 5 people, 38.46%
  5. Voriconazole: 5 people, 38.46%
  6. Mycophenolate Mofetil: 4 people, 30.77%
  7. Cyclophosphamide: 4 people, 30.77%
  8. Etoposide: 4 people, 30.77%
  9. Prednisone: 4 people, 30.77%
  10. Campath: 3 people, 23.08%

What are other side effects people have besides Acanthamoeba infection? *

  1. Pseudomonal Sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas): 6 people, 46.15%
  2. Leukopenia (less number of white blood cells in blood): 3 people, 23.08%
  3. Red Blood Cell Count Decreased: 2 people, 15.38%
  4. Liver Function Tests Nos Abnormal: 2 people, 15.38%
  5. Fever: 2 people, 15.38%
  6. Rash Erythematous (redness of the skin): 2 people, 15.38%
  7. White Blood Cell Count Decreased: 2 people, 15.38%
  8. Central Nervous System Lesion (an abnormality in tissue of brain or spinal cord): 1 person, 7.69%
  9. Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 1 person, 7.69%
  10. Cerebral Haemorrhage (bleeding within the brain): 1 person, 7.69%

What are the existing conditions these people have? *

  1. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 30.77%
  2. Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 4 people, 30.77%
  3. Epstein-Barr Virus Associated Lymphoproliferative Disorder (lymphocytes are produced in excessive quantities associated with epstein-barr virus): 2 people, 15.38%
  4. Post Transplant Lymphoproliferative Disorder: 1 person, 7.69%
  5. Pneumonia: 1 person, 7.69%
  6. Keratitis Herpetic (inflammation of the cornea due to infection of a present or previous herpes simplex virus): 1 person, 7.69%
  7. Immunodeficiency Disorders: 1 person, 7.69%
  8. Human Herpesvirus 6 Infection: 1 person, 7.69%
  9. Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 1 person, 7.69%
  10. Graft Versus Host Disease In Liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Acanthamoeba infection?

- Check whether Acanthamoeba infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acyclovir:

Acanthamoeba infection treatments and more:

How severe was Acanthamoeba infection and when was it recovered:

Expand to all the drugs that have ingredients of acyclovir:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acanthamoeba infection:

Browse all the conditions that are associated with Acanthamoeba infection:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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