Acyclovir and Hyporeflexia - a phase IV clinical study of FDA data

Summary:

Hyporeflexia is reported as a side effect among people who take Acyclovir (acyclovir), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Fluconazole, and have Encephalitis.

The phase IV clinical study analyzes which people have Hyporeflexia when taking Acyclovir. It is created by eHealthMe based on reports of 53,484 people who have side effects when taking Acyclovir from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Hyporeflexia?

Hyporeflexia (a condition of below normal or absent reflexes) is found to be associated with 501 drugs and 591 conditions by eHealthMe. Check the latest studies of Hyporeflexia.

On Jan, 21, 2026

53,484 people reported to have side effects when taking Acyclovir.
Among them, 15 people (0.03%) have Hyporeflexia.

Among these 15 people:

How long have people been on Acyclovir when they have Hyporeflexia? *

What is the gender of people who have Hyporeflexia when taking Acyclovir? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Hyporeflexia when taking Acyclovir? *

What are other drugs people take besides Acyclovir? *

What are other side effects people have besides Hyporeflexia? *

Weakness: 4 people, 26.67%
Respiratory Distress (difficulty in breathing): 4 people, 26.67%
Multi-Organ Failure (multisystem organ failure): 4 people, 26.67%
Hypoaesthesia (reduced sense of touch or sensation): 4 people, 26.67%
Thrombocytopenia (decrease of platelets in blood): 4 people, 26.67%
Ventricular Fibrillation (abnormally irregular heart rhythm): 3 people, 20.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 20.00%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 20.00%
Fall: 3 people, 20.00%
Venous Thrombosis Deep Limb (blood clot that forms in a vein deep in the limb): 3 people, 20.00%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.67%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 6.67%
Pain: 1 person, 6.67%
Nausea And Vomiting: 1 person, 6.67%
Muscle Spasms (muscle contraction): 1 person, 6.67%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
Meningoencephalitis Herpetic (inflammation of the brain and meninges by virus): 1 person, 6.67%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 1 person, 6.67%
Fever: 1 person, 6.67%
Encephalitis (inflammation of the brain): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Hyporeflexia?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acyclovir:

Acyclovir (54,961 reports)

Hyporeflexia treatments and more:

Hyporeflexia (3,443 reports)

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyporeflexia:

Hyporeflexia (501 drugs)

Browse all the conditions that are associated with Hyporeflexia:

Hyporeflexia (591 conditions)

Drugs similar to Acyclovir and Hyporeflexia :

Valtrex side effect: Hyporeflexia

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.