Acyclovir and Roundback - a phase IV clinical study of FDA data

Summary:

Roundback is reported as a side effect among people who take Acyclovir (acyclovir), especially for people who are male, 60+ old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Roundback when taking Acyclovir. It is created by eHealthMe based on reports of 53,484 people who have side effects when taking Acyclovir from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Roundback?

Roundback (abnormal rearward curvature of the spine) is found to be associated with 1,203 drugs and 731 conditions by eHealthMe. Check the latest studies of Roundback.

On Jan, 20, 2026

53,484 people reported to have side effects when taking Acyclovir.
Among them, 28 people (0.05%) have Roundback.

Among these 28 people:

What is the gender of people who have Roundback when taking Acyclovir? *

female: 48.15 %
male: 51.85 %

What is the age of people who have Roundback when taking Acyclovir? *

What are other drugs people take besides Acyclovir? *

What are other side effects people have besides Roundback? *

Pain: 25 people, 89.29%
Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 85.71%
Weakness: 20 people, 71.43%
Osteoporosis (bones weak and more likely to break): 20 people, 71.43%
Thrombocytopenia (decrease of platelets in blood): 20 people, 71.43%
Rib Fracture: 20 people, 71.43%
Stress And Anxiety: 19 people, 67.86%
Fever: 19 people, 67.86%
Infection: 18 people, 64.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 18 people, 64.29%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 50.00%
Osteoporosis (bones weak and more likely to break): 8 people, 28.57%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 7 people, 25.00%
Metastases To Bone (cancer spreads to bone): 3 people, 10.71%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 7.14%
Anaemia (lack of blood): 2 people, 7.14%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 3.57%
Renal Cell Carcinoma (a kidney cancer): 1 person, 3.57%
Quit Smoking: 1 person, 3.57%
Neoplasm Malignant (cancer tumour): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Roundback?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acyclovir:

Acyclovir (54,961 reports)

Roundback treatments and more:

Roundback (3,242 reports)

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Roundback:

Roundback (1,203 drugs)

Browse all the conditions that are associated with Roundback:

Roundback (731 conditions)

Drugs similar to Acyclovir and Roundback :

Valtrex side effect: Roundback

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.