Acyclovir and Systemic inflammatory response syndrome - a phase IV clinical study of FDA data

Summary:

Systemic inflammatory response syndrome is reported as a side effect among people who take Acyclovir (acyclovir), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Fluconazole, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Systemic inflammatory response syndrome when taking Acyclovir. It is created by eHealthMe based on reports of 53,484 people who have side effects when taking Acyclovir from the FDA, and is updated regularly.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

What is Systemic inflammatory response syndrome?

Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection) is found to be associated with 577 drugs and 903 conditions by eHealthMe. Check the latest studies of Systemic inflammatory response syndrome.

On May, 01, 2026

53,484 people reported to have side effects when taking Acyclovir.
Among them, 47 people (0.09%) have Systemic inflammatory response syndrome.

Could Acyclovir cause Systemic inflammatory response syndrome?

Among these 47 people:

How long have people been on Acyclovir when they have Systemic inflammatory response syndrome? *

What is the gender of people who have Systemic inflammatory response syndrome when taking Acyclovir? *

female: 17.5 %
male: 82.5 %

What is the age of people who have Systemic inflammatory response syndrome when taking Acyclovir? *

What are other drugs people take besides Acyclovir? *

Fluconazole: 16 people, 34.04%
Allopurinol: 13 people, 27.66%
Dexamethasone: 11 people, 23.40%
Revlimid: 10 people, 21.28%
Mycophenolate Mofetil: 10 people, 21.28%
Cyclosporine: 9 people, 19.15%
Fludara: 8 people, 17.02%
Aspirin: 8 people, 17.02%
Campath: 8 people, 17.02%
Lorazepam: 7 people, 14.89%

What are other side effects people have besides Systemic inflammatory response syndrome? *

Hypotension (abnormally low blood pressure): 17 people, 36.17%
Acute Kidney Failure: 14 people, 29.79%
Death: 10 people, 21.28%
Pneumonia: 9 people, 19.15%
Cytomegalovirus Infection: 9 people, 19.15%
Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 17.02%
Rashes (redness): 8 people, 17.02%
Dehydration (dryness resulting from the removal of water): 7 people, 14.89%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 14.89%
Fatigue (feeling of tiredness): 6 people, 12.77%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 12.77%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 5 people, 10.64%
Pain: 4 people, 8.51%
Bone Marrow Conditioning Regimen: 4 people, 8.51%
Nausea (feeling of having an urge to vomit): 3 people, 6.38%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 2 people, 4.26%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 4.26%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 4.26%
High Blood Pressure: 2 people, 4.26%
Blood Fibrinogen Increased: 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Systemic inflammatory response syndrome?

- Check whether Systemic inflammatory response syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acyclovir:

Acyclovir (54,961 reports)

Systemic inflammatory response syndrome treatments and more:

Systemic inflammatory response syndrome (5,055 reports)

How severe was Systemic inflammatory response syndrome and when was it recovered:

Systemic inflammatory response syndrome in Acyclovir

Expand to all the drugs that have ingredients of acyclovir:

Systemic inflammatory response syndrome and drugs with ingredients of acyclovir

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic inflammatory response syndrome:

Systemic inflammatory response syndrome (577 drugs)

Browse all the conditions that are associated with Systemic inflammatory response syndrome:

Systemic inflammatory response syndrome (903 conditions)

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.