Adapalene and Depression aggravated - a phase IV clinical study of FDA data

Summary:

Depression aggravated is reported as a side effect among people who take Adapalene (adapalene), especially for people who are female, 30-39 old, also take Differin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Depression aggravated when taking Adapalene. It is created by eHealthMe based on reports of 174,652 people who have side effects when taking Adapalene from the FDA, and is updated regularly.

What is Adapalene?

Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.

What is Depression aggravated?

Depression aggravated is found to be associated with 2,368 drugs and 748 conditions by eHealthMe. Check the latest studies of Depression aggravated.

On Jul, 13, 2026

174,652 people reported to have side effects when taking Adapalene.
Among them, 46 people (0.03%) have Depression aggravated.

Could Adapalene cause Depression aggravated?

Among these 46 people:

What is the gender of people who have Depression aggravated when taking Adapalene? *

female: 84.09 %
male: 15.91 %

What is the age of people who have Depression aggravated when taking Adapalene? *

What are other drugs people take besides Adapalene? *

What are other side effects people have besides Depression aggravated? *

Stress And Anxiety: 28 people, 60.87%
Pain: 23 people, 50.00%
Injury: 21 people, 45.65%
Weight Decreased: 21 people, 45.65%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 21 people, 45.65%
Fall: 20 people, 43.48%
Dyspnea (difficult or laboured breathing): 20 people, 43.48%
High Blood Pressure: 20 people, 43.48%
Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 41.30%
Heart Rate Irregular: 19 people, 41.30%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 34.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.87%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 4.35%
Stress And Anxiety: 2 people, 4.35%
Birth Control: 2 people, 4.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 4.35%
Pain: 2 people, 4.35%
Nausea (feeling of having an urge to vomit): 2 people, 4.35%
Hiv Infection: 2 people, 4.35%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Adapalene and have Depression aggravated?

- Check whether Depression aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adapalene:

Adapalene (174,662 reports)

Browse all side effects of Adapalene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression aggravated:

Depression aggravated (2,368 drugs)

Browse all the conditions that are associated with Depression aggravated:

Depression aggravated (748 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Adapalene) and Adapalene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.