Adapalene and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Adapalene (adapalene), especially for people who are female, 60+ old, also take Flexeril, and have Osteoporosis.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Adapalene. It is created by eHealthMe based on reports of 174,652 people who have side effects when taking Adapalene from the FDA, and is updated regularly.

What is Adapalene?

Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,318 drugs and 1,493 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

On May, 02, 2026

174,652 people reported to have side effects when taking Adapalene.
Among them, 19 people (0.01%) have Intervertebral disc degeneration.

Could Adapalene cause Intervertebral disc degeneration?

Among these 19 people:

What is the gender of people who have Intervertebral disc degeneration when taking Adapalene? *

female: 94.44 %
male: 5.56 %

What is the age of people who have Intervertebral disc degeneration when taking Adapalene? *

What are other drugs people take besides Adapalene? *

What are other side effects people have besides Intervertebral disc degeneration? *

Anhedonia (inability to experience pleasure from activities usually found enjoyable): 19 people, 100.00%
Pain: 19 people, 100.00%
Osteopenia (a condition where bone mineral density is lower than normal): 19 people, 100.00%
Depression: 19 people, 100.00%
Stress And Anxiety: 19 people, 100.00%
Hypovolaemia (a decreased volume of circulating blood in the body): 18 people, 94.74%
Osteomyelitis Chronic (long lasting infection of bone marrow): 18 people, 94.74%
Fall: 18 people, 94.74%
Gastritis (inflammation of stomach): 18 people, 94.74%
Osteoporosis (bones weak and more likely to break): 18 people, 94.74%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 84.21%
Sinus Disorder (disease of sinus): 1 person, 5.26%
Hiv Infection: 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Adapalene and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adapalene:

Adapalene (174,662 reports)

Browse all side effects of Adapalene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,318 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,493 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Adapalene) and Adapalene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.