Adcirca and Underactive thyroid - a phase IV clinical study of FDA data

Summary:

Underactive thyroid is reported as a side effect among people who take Adcirca (tadalafil), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Underactive thyroid when taking Adcirca. It is created by eHealthMe based on reports of 54,899 people who have side effects when taking Adcirca from the FDA, and is updated regularly.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

What is Underactive thyroid?

Underactive thyroid is found to be associated with 2,719 drugs and 2,641 conditions by eHealthMe. Check the latest studies of Underactive thyroid.

On Apr, 10, 2026

54,899 people reported to have side effects when taking Adcirca.
Among them, 77 people (0.14%) have Underactive thyroid.

Could Adcirca cause Underactive thyroid?

Among these 77 people:

How long have people been on Adcirca when they have Underactive thyroid? *

What is the gender of people who have Underactive thyroid when taking Adcirca? *

female: 70.83 %
male: 29.17 %

What is the age of people who have Underactive thyroid when taking Adcirca? *

What are other drugs people take besides Adcirca? *

What are other side effects people have besides Underactive thyroid? *

Nausea (feeling of having an urge to vomit): 23 people, 29.87%
Dyspnea (difficult or laboured breathing): 21 people, 27.27%
Headache (pain in head): 18 people, 23.38%
Diarrhea: 16 people, 20.78%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 15 people, 19.48%
Thrombocytopenia (decrease of platelets in blood): 15 people, 19.48%
Oedema Peripheral (superficial swelling): 13 people, 16.88%
Pneumonia: 13 people, 16.88%
Fluid Overload (too much fluid in the blood): 13 people, 16.88%
Anaemia (lack of blood): 13 people, 16.88%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 70 people, 90.91%
Cardiac Failure: 12 people, 15.58%
Insomnia (sleeplessness): 7 people, 9.09%
Back Pain: 7 people, 9.09%
Infusion Site Pain: 6 people, 7.79%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 6 people, 7.79%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 5 people, 6.49%
Neuropathy Peripheral (surface nerve damage): 5 people, 6.49%
Depression: 5 people, 6.49%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

Do you take Adcirca and have Underactive thyroid?

- Check whether Underactive thyroid is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adcirca:

Adcirca (54,957 reports)

Browse all side effects of Adcirca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Underactive thyroid:

Underactive thyroid (2,719 drugs)

Browse all the conditions that are associated with Underactive thyroid:

Underactive thyroid (2,641 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tadalafil (the active ingredients of Adcirca) and Adcirca (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.