Adempas and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Adempas (riociguat), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Pulmonary hypertension.

The phase IV clinical study analyzes which people have C. diff when taking Adempas. It is created by eHealthMe based on reports of 29,726 people who have side effects when taking Adempas from the FDA, and is updated regularly.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

What is C. diff?

C. diff is found to be associated with 1,573 drugs and 1,776 conditions by eHealthMe. Check the latest studies of C. diff.

On Apr, 24, 2026

29,726 people reported to have side effects when taking Adempas.
Among them, 32 people (0.11%) have C. diff.

Among these 32 people:

How long have people been on Adempas when they have C. diff? *

What is the gender of people who have C. diff when taking Adempas? *

female: 90.62 %
male: 9.38 %

What is the age of people who have C. diff when taking Adempas? *

What are other drugs people take besides Adempas? *

What are other side effects people have besides C. diff? *

Diarrhea: 16 people, 50.00%
Hypotension (abnormally low blood pressure): 14 people, 43.75%
Dyspnea (difficult or laboured breathing): 12 people, 37.50%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 31.25%
Dyspnea Exertional: 10 people, 31.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 10 people, 31.25%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 9 people, 28.12%
Haemoglobin Decreased: 9 people, 28.12%
Fatigue (feeling of tiredness): 9 people, 28.12%
Haematochezia (passage of stools containing blood): 9 people, 28.12%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 16 people, 50.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 13 people, 40.62%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 2 people, 6.25%
Diarrhea: 2 people, 6.25%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 1 person, 3.12%
High Blood Pressure: 1 person, 3.12%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 3.12%
Dyslipidaemia (abnormal amount of lipids): 1 person, 3.12%
Folate Deficiency (lack of folic acid): 1 person, 3.12%
Gastric Ulcer (stomach ulcer): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Adempas and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adempas:

Adempas (29,741 reports)

C. diff treatments and more:

C. diff (13,845 reports)

Browse all side effects of Adempas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. diff:

C. diff (1,573 drugs)

Browse all the conditions that are associated with C. diff:

C. diff (1,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on riociguat (the active ingredients of Adempas) and Adempas (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.