Adempas and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Adempas (riociguat), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Mental status changes when taking Adempas. It is created by eHealthMe based on reports of 29,726 people who have side effects when taking Adempas from the FDA, and is updated regularly.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,741 Adempas users. Check the latest studies of Adempas.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,491 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

29,726 people reported to have side effects when taking Adempas.
Among them, 70 people (0.24%) have Mental status changes.

Could Adempas cause Mental status changes?

Among these 70 people:

How long have people been on Adempas when they have Mental status changes? *

What is the gender of people who have Mental status changes when taking Adempas? *

female: 81.16 %
male: 18.84 %

What is the age of people who have Mental status changes when taking Adempas? *

What are other drugs people take besides Adempas? *

What are other side effects people have besides Mental status changes? *

Hypotension (abnormally low blood pressure): 23 people, 32.86%
Dyspnea (difficult or laboured breathing): 18 people, 25.71%
Nausea (feeling of having an urge to vomit): 17 people, 24.29%
Confusional State: 17 people, 24.29%
Diarrhea: 17 people, 24.29%
Headache (pain in head): 15 people, 21.43%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 14 people, 20.00%
Anaemia (lack of blood): 12 people, 17.14%
Pneumonia: 11 people, 15.71%
Cardiac Failure: 11 people, 15.71%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 58 people, 82.86%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 17.14%
Portopulmonary Hypertension (coexistence of portal and pulmonary hypertension): 3 people, 4.29%
Pain: 3 people, 4.29%
Oedema (fluid collection in tissue): 2 people, 2.86%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 1.43%
Essential Hypertension (primary hypertension): 1 person, 1.43%
Cor Pulmonale Chronic (long lasting enlargement of the right ventricle of the heart): 1 person, 1.43%

* Approximation only. Some reports may have incomplete information.

Do you take Adempas and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adempas:

Adempas (29,741 reports)

Browse all side effects of Adempas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,491 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on riociguat (the active ingredients of Adempas) and Adempas (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.