Adempas and Presyncope - a phase IV clinical study of FDA data

Summary:

Presyncope is reported as a side effect among people who take Adempas (riociguat), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Presyncope when taking Adempas. It is created by eHealthMe based on reports of 29,726 people who have side effects when taking Adempas from the FDA, and is updated regularly.

What is Adempas?

Adempas has active ingredients of riociguat. eHealthMe is studying from 29,740 Adempas users. Check the latest studies of Adempas.

What is Presyncope?

Presyncope is found to be associated with 1,440 drugs and 1,274 conditions by eHealthMe. Check the latest studies of Presyncope.

On Sep, 21, 2025

29,726 people reported to have side effects when taking Adempas.
Among them, 309 people (1.04%) have Presyncope.

Among these 309 people:

How long have people been on Adempas when they have Presyncope? *

What is the gender of people who have Presyncope when taking Adempas? *

female: 78.96 %
male: 21.04 %

What is the age of people who have Presyncope when taking Adempas? *

What are other drugs people take besides Adempas? *

What are other side effects people have besides Presyncope? *

Dizziness: 186 people, 60.19%
Hypotension (abnormally low blood pressure): 150 people, 48.54%
Dyspnea (difficult or laboured breathing): 125 people, 40.45%
Fatigue (feeling of tiredness): 105 people, 33.98%
Headache (pain in head): 104 people, 33.66%
Diarrhea: 87 people, 28.16%
Nausea (feeling of having an urge to vomit): 77 people, 24.92%
Dyspnea Exertional: 74 people, 23.95%
Chest Pain: 61 people, 19.74%
Nausea And Vomiting: 56 people, 18.12%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 241 people, 77.99%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 64 people, 20.71%
Pulmonary Embolism (blockage of the main artery of the lung): 7 people, 2.27%
Pain: 3 people, 0.97%
Immune System Disorder: 3 people, 0.97%
Heart Disease: 3 people, 0.97%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 2 people, 0.65%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 0.65%
Bleeding Disorders: 2 people, 0.65%
Asthma: 2 people, 0.65%

* Approximation only. Some reports may have incomplete information.

Do you take Adempas and have Presyncope?

- Check whether Presyncope is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Adempas:

Adempas (29,740 reports)

Presyncope treatments and more:

Presyncope (26,156 reports)

Common Adempas side effects:

Browse all side effects of Adempas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Presyncope:

Browse all the drugs that are associated with Presyncope:

Presyncope (1,440 drugs)

Common conditions associated with Presyncope:

Htn: 2,243 reports
Pulmonary arterial hypertension: 1,438 reports
Pain: 805 reports
Pain relief: 798 reports
Pregnancy: 785 reports
Depression: 734 reports
Ra: 699 reports
A-fib: 632 reports
Osteoporosis: 608 reports
Ms: 592 reports

Browse all the conditions that are associated with Presyncope:

Presyncope (1,274 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on riociguat (the active ingredients of Adempas) and Adempas (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.