Advair hfa and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Advair hfa (fluticasone propionate; salmeterol xinafoate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Singulair, and have Narcolepsy.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Advair hfa. It is created by eHealthMe based on reports of 69,236 people who have side effects when taking Advair hfa from the FDA, and is updated regularly.

What is Advair hfa?

Advair hfa has active ingredients of fluticasone propionate; salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 69,788 Advair hfa users. Check the latest studies of Advair hfa.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,271 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Sep, 25, 2025

69,236 people reported to have side effects when taking Advair hfa.
Among them, 17 people (0.02%) have Sinus node dysfunction.

Could Advair hfa cause Sinus node dysfunction?

Among these 17 people:

How long have people been on Advair hfa when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Advair hfa? *

female: 82.35 %
male: 17.65 %

What is the age of people who have Sinus node dysfunction when taking Advair hfa? *

What are other drugs people take besides Advair hfa? *

What are other side effects people have besides Sinus node dysfunction? *

Cardiac Disorder: 5 people, 29.41%
Post-Traumatic Stress Disorder: 5 people, 29.41%
High Blood Pressure: 5 people, 29.41%
Depression: 4 people, 23.53%
Anaemia (lack of blood): 3 people, 17.65%
Vision Blurred: 3 people, 17.65%
Gastric Ulcer (stomach ulcer): 3 people, 17.65%
Dizziness: 3 people, 17.65%
Suicidal Ideation: 3 people, 17.65%
White Blood Cell Count Increased: 2 people, 11.76%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 41.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 35.29%
Neuropathy Peripheral (surface nerve damage): 5 people, 29.41%
Multiple Myeloma (cancer of the plasma cells): 4 people, 23.53%
Intervertebral Disc Protrusion (spinal disc protrusion): 4 people, 23.53%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 23.53%
Haemoglobin Decreased: 4 people, 23.53%
High Blood Pressure: 3 people, 17.65%
Blood Potassium Decreased: 2 people, 11.76%
Drowsiness: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Advair hfa and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advair hfa:

Advair hfa (69,788 reports)

Sinus node dysfunction treatments and more:

Sinus node dysfunction (4,617 reports)

How severe was Sinus node dysfunction and when was it recovered:

Sinus node dysfunction in Advair hfa

Expand to all the drugs that have ingredients of fluticasone propionate; salmeterol xinafoate:

Sinus node dysfunction and drugs with ingredients of fluticasone propionate; salmeterol xinafoate (77 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advair hfa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,271 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (834 conditions)

Drugs similar to Advair hfa and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate; salmeterol xinafoate (the active ingredients of Advair hfa) and Advair hfa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.