Advil pm and Diarrhea - a phase IV clinical study of FDA data

Summary:

Diarrhea is reported as a side effect among people who take Advil pm (diphenhydramine hydrochloride; ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Advil, and have Hepatitis c.

The phase IV clinical study analyzes which people have Diarrhea when taking Advil pm. It is created by eHealthMe based on reports of 1,146 people who have side effects when taking Advil pm from the FDA, and is updated regularly.

What is Advil pm?

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. eHealthMe is studying from 1,445 Advil pm users. Check the latest studies of Advil pm.

What is Diarrhea?

Diarrhea is found to be associated with 3,720 drugs and 5,754 conditions by eHealthMe. Check the latest studies of Diarrhea.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,146 people reported to have side effects when taking Advil pm.
Among them, 25 people (2.18%) have Diarrhea.

Among these 25 people:

How long have people been on Advil pm when they have Diarrhea? *

What is the gender of people who have Diarrhea when taking Advil pm? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Diarrhea when taking Advil pm? *

What are other drugs people take besides Advil pm? *

Advil: 5 people, 20.00%
Melatonin: 4 people, 16.00%
Vitamin D: 3 people, 12.00%
Incivek: 3 people, 12.00%
Fish Oil: 3 people, 12.00%
Centrum Silver: 2 people, 8.00%
Humira: 2 people, 8.00%
Vitamin E: 2 people, 8.00%
Oxycodone Hydrochloride: 2 people, 8.00%
Pegasys: 2 people, 8.00%

What are other side effects people have besides Diarrhea? *

Nausea (feeling of having an urge to vomit): 5 people, 20.00%
Nausea And Vomiting: 5 people, 20.00%
Rashes (redness): 5 people, 20.00%
Abdominal Discomfort: 3 people, 12.00%
Fatigue (feeling of tiredness): 3 people, 12.00%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 3 people, 12.00%
Itching: 3 people, 12.00%
Abdominal Pain Upper: 2 people, 8.00%
Abdominal Pain: 2 people, 8.00%
Muscle Spasms (muscle contraction): 2 people, 8.00%

What are the existing conditions these people have? *

Joint Pain: 3 people, 12.00%
Hepatitis C: 3 people, 12.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 8.00%
High Blood Cholesterol: 2 people, 8.00%
Sleep Disorder: 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Arthropathy: 1 person, 4.00%
Cardiac Disorder: 1 person, 4.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.00%
Diabetes: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Advil pm and have Diarrhea?

- Check whether Diarrhea is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil pm:

Advil pm (1,445 reports)

Diarrhea treatments and more:

Diarrhea (756,291 reports)

How severe was Diarrhea and when was it recovered:

Diarrhea in Advil pm

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride; ibuprofen:

Diarrhea and drugs with ingredients of diphenhydramine hydrochloride; ibuprofen (50 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advil pm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diarrhea:

Diarrhea (3,720 drugs)

Browse all the conditions that are associated with Diarrhea:

Diarrhea (5,754 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride; ibuprofen (the active ingredients of Advil pm) and Advil pm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.