Advil pm and Middle insomnia - a phase IV clinical study of FDA data

Summary:

Middle insomnia is reported as a side effect among people who take Advil pm (diphenhydramine hydrochloride; ibuprofen), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Advil, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Middle insomnia when taking Advil pm. It is created by eHealthMe based on reports of 1,146 people who have side effects when taking Advil pm from the FDA, and is updated regularly.

What is Advil pm?

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. eHealthMe is studying from 1,445 Advil pm users. Check the latest studies of Advil pm.

What is Middle insomnia?

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 987 drugs and 970 conditions by eHealthMe. Check the latest studies of Middle insomnia.

On Jul, 27, 2026

1,146 people reported to have side effects when taking Advil pm.
Among them, 19 people (1.66%) have Middle insomnia.

Among these 19 people:

How long have people been on Advil pm when they have Middle insomnia? *

What is the gender of people who have Middle insomnia when taking Advil pm? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Middle insomnia when taking Advil pm? *

What are other drugs people take besides Advil pm? *

What are other side effects people have besides Middle insomnia? *

Drug Ineffective: 6 people, 31.58%
Feeling Abnormal: 3 people, 15.79%
Fatigue (feeling of tiredness): 2 people, 10.53%
Weight Decreased: 1 person, 5.26%
Skin Blushing/flushing (a sudden reddening of the face, neck): 1 person, 5.26%
Confusion: 1 person, 5.26%
Dry Mouth: 1 person, 5.26%
Feeling Hot: 1 person, 5.26%
Hyperhidrosis (abnormally increased sweating): 1 person, 5.26%
Hypervigilance: 1 person, 5.26%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 15.79%
High Blood Cholesterol: 3 people, 15.79%
Sleep Disorder: 2 people, 10.53%
Neck Pain: 2 people, 10.53%
Tendonitis (a condition that causes pain and swelling of tendons): 1 person, 5.26%
Pain In Extremity: 1 person, 5.26%
Low Density Lipoprotein Increased (cholesterol increased in blood): 1 person, 5.26%
Joint Pain: 1 person, 5.26%
Itching: 1 person, 5.26%
High Density Lipoprotein Decreased: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Advil pm and have Middle insomnia?

- Check whether Middle insomnia is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil pm:

Advil pm (1,445 reports)

Middle insomnia treatments and more:

Middle insomnia (21,952 reports)

How severe was Middle insomnia and when was it recovered:

Middle insomnia in Advil pm

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride; ibuprofen:

Middle insomnia and drugs with ingredients of diphenhydramine hydrochloride; ibuprofen

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advil pm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle insomnia:

Middle insomnia (987 drugs)

Browse all the conditions that are associated with Middle insomnia:

Middle insomnia (970 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride; ibuprofen (the active ingredients of Advil pm) and Advil pm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.