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Advil and Metabolic encephalopathy - a phase IV clinical study of FDA data

Summary:

Metabolic encephalopathy is reported as a side effect among people who take Advil (ibuprofen), especially for people who are female, 60+ old, also take Symbicort, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Metabolic encephalopathy when taking Advil. It is created by eHealthMe based on reports of 60,378 people who have side effects when taking Advil from the FDA, and is updated regularly.

What is Advil?

Advil has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 62,533 Advil users. Check the latest studies of Advil.

What is Metabolic encephalopathy?

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy) is found to be associated with 552 drugs and 588 conditions by eHealthMe. Check the latest studies of Metabolic encephalopathy.

On Jul, 20, 2026

60,378 people reported to have side effects when taking Advil.
Among them, 17 people (0.03%) have Metabolic encephalopathy.

Could Advil cause Metabolic encephalopathy?

Among these 17 people:

What is the gender of people who have Metabolic encephalopathy when taking Advil? *

  • female: 70.59 %
  • male: 29.41 %

What is the age of people who have Metabolic encephalopathy when taking Advil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 6.25 %
  • 30-39: 6.25 %
  • 40-49: 12.5 %
  • 50-59: 0.0 %
  • 60+: 75.0 %

What are other drugs people take besides Advil? *

  1. Lidocaine And Prilocaine: 8 people, 47.06%
  2. Norco: 8 people, 47.06%
  3. Miralax: 8 people, 47.06%
  4. Symbicort: 8 people, 47.06%
  5. Tramadol: 7 people, 41.18%
  6. Furosemide: 7 people, 41.18%
  7. Klor-Con: 6 people, 35.29%
  8. Albuterol Sulfate: 6 people, 35.29%
  9. Olmesartan Medoxomil: 6 people, 35.29%
  10. Pantoprazole Sodium: 6 people, 35.29%

What are other side effects people have besides Metabolic encephalopathy? *

  1. Thrombocytopenia (decrease of platelets in blood): 11 people, 64.71%
  2. Confusional State: 9 people, 52.94%
  3. Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 4 people, 23.53%
  4. Aspartate Aminotransferase Increased: 4 people, 23.53%
  5. Alanine Aminotransferase Increased: 4 people, 23.53%
  6. Urinary Tract Infection: 3 people, 17.65%
  7. Hepatic Enzyme Increased: 3 people, 17.65%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 17.65%
  9. Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 11.76%
  10. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 11.76%

What are the existing conditions these people have? *

  1. Breast Cancer Metastatic: 8 people, 47.06%
  2. High Blood Pressure: 5 people, 29.41%
  3. Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 5 people, 29.41%
  4. Constipation: 5 people, 29.41%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 23.53%
  6. Nausea (feeling of having an urge to vomit): 4 people, 23.53%
  7. Depression: 4 people, 23.53%
  8. Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 23.53%
  9. Hypokalemia (low potassium): 4 people, 23.53%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Advil and have Metabolic encephalopathy?

- Check whether Metabolic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Advil:

Metabolic encephalopathy treatments and more:

How severe was Metabolic encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of ibuprofen:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Advil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic encephalopathy:

Browse all the conditions that are associated with Metabolic encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Advil) and Advil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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