Aldactazide and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Aldactazide (hydrochlorothiazide; spironolactone), especially for people who are male, 60+ old, also take Metformin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Constipation when taking Aldactazide. It is created by eHealthMe based on reports of 1,564 people who have side effects when taking Aldactazide from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,619 conditions by eHealthMe. Check the latest studies of Constipation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

1,564 people reported to have side effects when taking Aldactazide.
Among them, 40 people (2.56%) have Constipation.

Among these 40 people:

What is the gender of people who have Constipation when taking Aldactazide? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Constipation when taking Aldactazide? *

What are other drugs people take besides Aldactazide? *

What are other side effects people have besides Constipation? *

Fatigue (feeling of tiredness): 12 people, 30.00%
Acute Kidney Failure: 11 people, 27.50%
Nausea And Vomiting: 9 people, 22.50%
Weakness: 8 people, 20.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 7 people, 17.50%
Irritable Bowel Syndrome: 7 people, 17.50%
Swallowing Difficulty: 7 people, 17.50%
Rashes (redness): 7 people, 17.50%
Osteoporosis (bones weak and more likely to break): 6 people, 15.00%
Pain In Jaw: 6 people, 15.00%

What are the existing conditions these people have? *

Prostate Cancer: 6 people, 15.00%
Multiple Myeloma (cancer of the plasma cells): 6 people, 15.00%
High Blood Cholesterol: 3 people, 7.50%
Pain: 3 people, 7.50%
Type 2 Diabetes: 2 people, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.00%
Itching: 2 people, 5.00%
Hypersensitivity: 2 people, 5.00%
Quit Smoking: 2 people, 5.00%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and have Constipation?

- Check whether Constipation is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactazide:

Aldactazide (1,597 reports)

Constipation treatments and more:

Constipation (337,881 reports)

How severe was Constipation and when was it recovered:

Constipation in Aldactazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; spironolactone:

Constipation and drugs with ingredients of hydrochlorothiazide; spironolactone (55 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aldactazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,619 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; spironolactone (the active ingredients of Aldactazide) and Aldactazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.