Aldactazide and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Aldactazide (hydrochlorothiazide; spironolactone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Calcium, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Fatigue when taking Aldactazide. It is created by eHealthMe based on reports of 1,564 people who have side effects when taking Aldactazide from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,026 drugs and 6,379 conditions by eHealthMe. Check the latest studies of Fatigue.

On Jul, 10, 2026

1,564 people reported to have side effects when taking Aldactazide.
Among them, 71 people (4.54%) have Fatigue.

Among these 71 people:

How long have people been on Aldactazide when they have Fatigue? *

What is the gender of people who have Fatigue when taking Aldactazide? *

female: 67.14 %
male: 32.86 %

What is the age of people who have Fatigue when taking Aldactazide? *

What are other drugs people take besides Aldactazide? *

What are other side effects people have besides Fatigue? *

Dyspnea (difficult or laboured breathing): 18 people, 25.35%
Weakness: 17 people, 23.94%
Nausea (feeling of having an urge to vomit): 15 people, 21.13%
Diarrhea: 14 people, 19.72%
Constipation: 12 people, 16.90%
Joint Pain: 12 people, 16.90%
Oedema Peripheral (superficial swelling): 11 people, 15.49%
Fever: 11 people, 15.49%
Weight Decreased: 10 people, 14.08%
Weight Increased: 10 people, 14.08%

What are the existing conditions these people have? *

High Blood Cholesterol: 8 people, 11.27%
Prostate Cancer: 6 people, 8.45%
Multiple Myeloma (cancer of the plasma cells): 5 people, 7.04%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 7.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.04%
Diabetes: 5 people, 7.04%
Pain: 5 people, 7.04%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 5.63%
Type 2 Diabetes: 3 people, 4.23%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 3 people, 4.23%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactazide:

Aldactazide (1,597 reports)

Fatigue treatments and more:

Fatigue (967,537 reports)

How severe was Fatigue and when was it recovered:

Fatigue in Aldactazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; spironolactone:

Fatigue and drugs with ingredients of hydrochlorothiazide; spironolactone (188 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aldactazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,026 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,379 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; spironolactone (the active ingredients of Aldactazide) and Aldactazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.