Aldactazide and Hypotension - a phase IV clinical study of FDA data

Summary:

Hypotension is reported as a side effect among people who take Aldactazide (hydrochlorothiazide; spironolactone), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lasix, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Hypotension when taking Aldactazide. It is created by eHealthMe based on reports of 1,564 people who have side effects when taking Aldactazide from the FDA, and is updated regularly.

What is Aldactazide?

Aldactazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 1,597 Aldactazide users. Check the latest studies of Aldactazide.

What is Hypotension?

Hypotension (abnormally low blood pressure) is found to be associated with 3,354 drugs and 4,762 conditions by eHealthMe. Check the latest studies of Hypotension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 31, 2026

1,564 people reported to have side effects when taking Aldactazide.
Among them, 54 people (3.45%) have Hypotension.

Among these 54 people:

How long have people been on Aldactazide when they have Hypotension? *

What is the gender of people who have Hypotension when taking Aldactazide? *

female: 43.4 %
male: 56.6 %

What is the age of people who have Hypotension when taking Aldactazide? *

What are other drugs people take besides Aldactazide? *

What are other side effects people have besides Hypotension? *

Malaise (a feeling of general discomfort or uneasiness): 11 people, 20.37%
Weakness: 9 people, 16.67%
Hyperkalemia (damage to or disease of the kidney): 8 people, 14.81%
Acute Kidney Failure: 8 people, 14.81%
Heart Attack: 7 people, 12.96%
Fainting (loss of consciousness and postural tone): 6 people, 11.11%
Indigestion: 6 people, 11.11%
Dyspnea (difficult or laboured breathing): 6 people, 11.11%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 6 people, 11.11%
Ventricular Fibrillation (abnormally irregular heart rhythm): 5 people, 9.26%

What are the existing conditions these people have? *

High Blood Cholesterol: 6 people, 11.11%
Blood Pressure Abnormal: 3 people, 5.56%
Stress And Anxiety: 3 people, 5.56%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 3.70%
Enlarged Prostate: 2 people, 3.70%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 3.70%
Anaemia (lack of blood): 2 people, 3.70%
Heart Attack: 2 people, 3.70%
Cardiac Disorder: 2 people, 3.70%
Osteoporosis (bones weak and more likely to break): 2 people, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactazide and have Hypotension?

- Check whether Hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactazide:

Aldactazide (1,597 reports)

Hypotension treatments and more:

Hypotension (329,856 reports)

How severe was Hypotension and when was it recovered:

Hypotension in Aldactazide

Expand to all the drugs that have ingredients of hydrochlorothiazide; spironolactone:

Hypotension and drugs with ingredients of hydrochlorothiazide; spironolactone (74 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aldactazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypotension:

Hypotension (3,354 drugs)

Browse all the conditions that are associated with Hypotension:

Hypotension (4,762 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; spironolactone (the active ingredients of Aldactazide) and Aldactazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.