Aldactone and Cardiac pacemaker replacement - a phase IV clinical study of FDA data

Summary:

Cardiac pacemaker replacement is reported as a side effect among people who take Aldactone (spironolactone), especially for people who are female, 60+ old, also take Lasix, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Cardiac pacemaker replacement when taking Aldactone. It is created by eHealthMe based on reports of 45,404 people who have side effects when taking Aldactone from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

What is Cardiac pacemaker replacement?

Cardiac pacemaker replacement is found to be associated with 61 drugs and 203 conditions by eHealthMe. Check the latest studies of Cardiac pacemaker replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

45,404 people reported to have side effects when taking Aldactone.
Among them, 12 people (0.03%) have Cardiac pacemaker replacement.

Could Aldactone cause Cardiac pacemaker replacement?

Among these 12 people:

What is the gender of people who have Cardiac pacemaker replacement when taking Aldactone? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Cardiac pacemaker replacement when taking Aldactone? *

What are other drugs people take besides Aldactone? *

What are other side effects people have besides Cardiac pacemaker replacement? *

Fall: 6 people, 50.00%
Head Injury: 5 people, 41.67%
Foot Fracture: 4 people, 33.33%
Cholecystitis Infective (infection of gallbladder capable to infect other organs): 3 people, 25.00%
Upper Limb Fracture: 3 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 25.00%
Coronary Artery Occlusion (complete obstruction of blood flow in a coronary artery): 3 people, 25.00%
Fatigue (feeling of tiredness): 2 people, 16.67%
Pleural Effusion (water on the lungs): 2 people, 16.67%
Pulmonary Oedema (fluid accumulation in the lungs): 2 people, 16.67%

What are the existing conditions these people have? *

Renal Disorder (kidney disease): 3 people, 25.00%
Parathyroid Disorder: 3 people, 25.00%
Gout (uric acid crystals building up in the body): 3 people, 25.00%
Immunodeficiency Common Variable: 3 people, 25.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 16.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 16.67%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Cardiac Disorder: 1 person, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactone and have Cardiac pacemaker replacement?

- Check whether Cardiac pacemaker replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactone:

Aldactone (46,063 reports)

Browse all side effects of Aldactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac pacemaker replacement:

Cardiac pacemaker replacement (61 drugs)

Browse all the conditions that are associated with Cardiac pacemaker replacement:

Cardiac pacemaker replacement (203 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Aldactone) and Aldactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.