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Aldactone and Weight fluctuation - a phase IV clinical study of FDA data

Summary:

Weight fluctuation is reported as a side effect among people who take Aldactone (spironolactone), especially for people who are male, 60+ old, also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Weight fluctuation when taking Aldactone. It is created by eHealthMe based on reports of 45,404 people who have side effects when taking Aldactone from the FDA, and is updated regularly.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,062 Aldactone users. Check the latest studies of Aldactone.

What is Weight fluctuation?

Weight fluctuation is found to be associated with 900 drugs and 1,020 conditions by eHealthMe. Check the latest studies of Weight fluctuation.

On May, 03, 2026

45,404 people reported to have side effects when taking Aldactone.
Among them, 36 people (0.08%) have Weight fluctuation.

Could Aldactone cause Weight fluctuation?

Among these 36 people:

What is the gender of people who have Weight fluctuation when taking Aldactone? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Weight fluctuation when taking Aldactone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 3.85 %
  • 20-29: 0.0 %
  • 30-39: 3.85 %
  • 40-49: 11.54 %
  • 50-59: 34.62 %
  • 60+: 46.15 %

What are other drugs people take besides Aldactone? *

  1. Lasix: 18 people, 50.00%
  2. Eliquis: 10 people, 27.78%
  3. Lexapro: 10 people, 27.78%
  4. Plaquenil: 8 people, 22.22%
  5. Letairis: 7 people, 19.44%
  6. Entresto: 7 people, 19.44%
  7. Orenitram: 6 people, 16.67%
  8. Revatio: 6 people, 16.67%
  9. Pepcid: 5 people, 13.89%
  10. Epipen: 5 people, 13.89%

What are other side effects people have besides Weight fluctuation? *

  1. Dizziness: 14 people, 38.89%
  2. Oedema Peripheral (superficial swelling): 11 people, 30.56%
  3. Diarrhea: 9 people, 25.00%
  4. Fatigue (feeling of tiredness): 9 people, 25.00%
  5. Rashes (redness): 9 people, 25.00%
  6. Weakness: 8 people, 22.22%
  7. Dyspnea (difficult or laboured breathing): 7 people, 19.44%
  8. Fever: 7 people, 19.44%
  9. Chest Pain: 7 people, 19.44%
  10. Pain: 6 people, 16.67%

What are the existing conditions these people have? *

  1. Cardiac Failure: 6 people, 16.67%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 16.67%
  3. Cardiac Disorder: 5 people, 13.89%
  4. High Blood Cholesterol: 4 people, 11.11%
  5. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 11.11%
  6. Pain: 3 people, 8.33%
  7. Depression: 3 people, 8.33%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 8.33%
  9. Adrenal Disorder: 2 people, 5.56%
  10. Dizziness: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Aldactone and have Weight fluctuation?

- Check whether Weight fluctuation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Aldactone:

Weight fluctuation treatments and more:

How severe was Weight fluctuation and when was it recovered:

Expand to all the drugs that have ingredients of spironolactone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Aldactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight fluctuation:

Browse all the conditions that are associated with Weight fluctuation:

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Aldactone) and Aldactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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